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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.

About

Research areas:

Toxinology, structural and functional characterization of neurotoxic and anticoagulant phospholipases A2 (sPLA2 group IIA) from snake venom, search for their molecular mechanism of action, identification of the neurotoxic and anticoagulant sites of these PLA2s (search for new anticoagulant (antithrombotic) and/or anti-neurotoxic agents), determination of the crystal structures of crotoxin and several neurotoxic phospholipases A2, SPR characterization of the binding of PLA2s with their protein targets (soluble and solubilized membrane-bound receptors), purification and characterization of natural inhibitor of toxic phospholipases A2 from blood of the snake, search for new allosteric modulators of pLGIC. PI of project: Rattlesnake phospholipase A2 as a new modulator (potentiator and corrector) of Cystic Fibrosis Transmembrane Regulator (CFTR)/DF508-CFTR, impact in cystic fibrosis.

Patents

CV

FAURE Grazyna, PhD, HDR

 Curriculum Vitae

 Birth place: Stalowa Wola, Poland

Current Position: Chargée de Recherche Expert (Research Scientist) in Pasteur Institute

Address: Institut Pasteur, Unité Récepteurs-Canaux, Departement Neurosciences, 25, rue du Dr Roux, 75724 Paris, France

University diplomas

1983    Ph.D. in Biochemistry, University of Paris VI (UPMC)

2001    HDR, University René Descartes of Paris V

Distinction 

2014    “Visiting Professor” in Department of Biochemistry of the Nicolaus Copernicus University in Torun (Poland)

Memberships:

International Society of Toxinology (IST)

Societé Française pour l’Etude des Toxines (SFET) (Administration Council 2012-2018)

Teaching responsibilities and training:

1996 – 2016: Lectures for Master 2 “Molecules et cibles therapeutiques” UPMC and Muséum National d’Histoire Naturelle in Paris

1999 – 2017: Lectures for “Venomous and Venenous Animals” Courses in MNHN

Scientific expert of Surface Plasmon Resonance technology in Pasteur Institute

Research director of 28 students.

Peer-reviewing for:

European Journal of Biochemistry; Biochimie; Toxicon; Biochemical Journal; BBA; Biochem. Biophys. Res. Comm.; FEBS Journal; Journal of Proteome Res.; Journal of Immunol. Meth.; Journal of Liquide Chromat & Rel. technologies; Comparatives Biochem.& Physiol; Intern. J. of Biochem & Cell Biol

Total number of publications:

Author of 78 publications with international committees. Participation to 160 congresses with more than 40 invitations as speaker around the world.

Patent

Faure, A. Edelman, N. Odolczyk, P. Zielenkiewicz

WO 2017/187274 A1

PCT/FR2017/051030  Methods and compositions for modifying cystic fibrosis transmembrane conductance regulator activity, déposée le 28 avril 2017 sous la priorité de la demande de brevet américain provisoire US 62/329,875 déposée le 29 avril 2016 aux noms de l’Institut Pasteur, l’INSERM et l’IBB -Academy of Sciences de Varsovie.

 

Publications

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