Renata Basto – Biology of centrosomes and genetic instability lab, UMR144, Institut Curie, Paris, France
Abstract: The processes that contribute to maintaining a stable (euploid) genome content in multicellular organisms are of vital importance. They ensure viability of stem and progenitor cells by contributing to their fitness and performance during both development and adulthood. In the germline, genome stability ensures the transmission of species-specific traits across generations. However, variations to the normal euploid genome content are frequently found in healthy animals and are thought to contribute with phenotypic variability in adverse situations. Yet they are also at the basis of several human diseases, including neuro-developmental disorders and cancer. In this talk I will discuss how tissue respond to variations in in whole chromosome number and their impact on organism homeostasis.