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GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection”

C3BI Seminar: Hierarchical functional genomics to interpret genome variation and dissect complex disease architecture

© Research

Event

Department seminar by Amar Deep Sharma, MHH, Hannover, Germany: “Regenerative Medicine for the Dysfunctional Liver”

Team: Cellular plasticity in age-related pathologies

Department of: Developmental and Stem Cell Biology

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

09

Mar 2018

Time

11:00:00

25 Rue du Dr Roux, Paris, France

Address

Building: Monod

Location

2018-03-09 11:00:00 2018-03-09 00:00:00 Europe/Paris Department seminar by Amar Deep Sharma, MHH, Hannover, Germany: “Regenerative Medicine for the Dysfunctional Liver” All End-stage chronic liver diseases contribute to more than 170,000 deaths per year in Europe. Scarcity of donor livers has led to the development of novel approaches in regenerative medicine for the treatment of […] 25 Rue du Dr Roux, Paris, France Han Li han.li@pasteur.fr

About

All End-stage chronic liver diseases contribute to more than 170,000 deaths per year in Europe. Scarcity of donor livers has led to the development of novel approaches in regenerative medicine for the treatment of life-threatening liver diseases. The recent research from my group has shown the generation of functionally improved hepatocytes from human pluripotent stem cells via microRNA modulation (J Hepatol. 62(1):101-10, 2015). Furthermore, we have discovered a combination of transcription factors that reprograms fibrosis-causing cells into functional hepatocytes in vivo, leading to amelioration of liver fibrosis (Cell Stem Cell 18, 797-808, 2016). Thus, in vivo direct reprogramming of fibrotic cells into functional parenchymal cells has the promising potential to become an innovative treatment option for end-stage liver diseases. Additionally, this approach would be applicable to chronic diseases of other organs such as lung and kidney, thereby potentially helping millions of patients, world-wide.

Location

Building: Monod
Address: 25 Rue du Dr Roux, Paris, France

Published on: 27 Feb 2018 • Modified on: 06 Mar 2018

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