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© Institut Pasteur
Phlébotome. Petit diptère de la famille des psychodidés (dans l'Ancien Monde). La femelle hématophage peut être vectrice entre autres de leishmaniose qu'elle transmet par piqûre à un vertébré, chien (hôte principal réservoir), homme ou encore rat (hôtes occasionnels).
Event

“Collateral damage during dengue virus infection: Making sense of DNA by cGAS” with Sebastian Aguirre -Virology department seminar

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
10
Apr 2018
Time
12:00:00
28 Rue du Docteur Roux, Paris, France
Address
Building: Centre François Jacob Room: Auditorium Centre François Jacob
Location
2018-04-10 12:00:00 2018-04-10 13:00:00 Europe/Paris “Collateral damage during dengue virus infection: Making sense of DNA by cGAS” with Sebastian Aguirre -Virology department seminar Sebastian AGUIRRE, PhD  Assistant Professor, Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA “Collateral damage during dengue virus infection: Making sense of DNA by cGAS”  Mardi 10 Avril […] 28 Rue du Docteur Roux, Paris, France Carla Saleh carla.saleh@pasteur.fr

About

Sebastian AGUIRRE, PhD

 Assistant Professor, Department of Microbiology,

Icahn School of Medicine at Mount Sinai, New York, NY, USA

Collateral damage during dengue virus infection: Making sense of DNA by cGAS”

 Mardi 10 Avril 2018 à 12h00

Auditorium Centre François Jacob

Invited by Gonzalo Moratorio (gonzalo.moratorio@pasteur.fr) and Carla Saleh (carla.saleh@pasteur.fr)  

Abstract :

For the last decades Dengue virus (DENV) has dramatically increased its global incidence, being now endemic in more than 100 countries. In order to stablish a productive infection in humans, DENV uses different strategies to inhibit or avoid the host innate immune system. Some studies have deciphered mechanisms that rely on viral proteins to strategically target crucial components of the type I IFN system. Here we report that the DNA sensor cGAS is involved in early detection of DENV infection, by recognizing misplaced host DNA. By using biochemical and immunofluorescence techniques, we demonstrate a novel mechanism by which cGAS sense cellular damage upon DENV infection. Furthermore, the NS2B protease co-factor specifically interacts with cGAS during infection and promotes its degradation in a lysosome dependent mechanism. This degradation results in an inhibition of the cGAS/STING cytosolic DNA sensing pathway in primary human dendritic cells.

Location

Building: Centre François Jacob
Room: Auditorium Centre François Jacob
Address: 28 Rue du Docteur Roux, Paris, France