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© Research
Event

C3BI Seminar – An evolutionary perspective on meiotic recombination in vertebrates

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
20
Dec 2018
Time
14:00:00
28 Rue du Dr Roux, 75015 Paris, France
Address
Building: BIME (#26) Room: Auditorium F. Jacob
Location
2018-12-20 14:00:00 2018-12-20 15:00:00 Europe/Paris C3BI Seminar – An evolutionary perspective on meiotic recombination in vertebrates Meiotic recombination is a fundamental genetic process that generates new combinations of alleles on which natural selection can act and ensures the proper alignment and segregation of chromosomes. Recombination events are initiated by double […] 28 Rue du Dr Roux, 75015 Paris, France Pascal Campagne pascal.campagne@pasteur.fr

About

Meiotic recombination is a fundamental genetic process that generates new combinations of alleles on which natural selection can act and ensures the proper alignment and segregation of chromosomes. Recombination events are initiated by double strand breaks deliberately inflicted on the genome during meiosis. As I will discuss, in vertebrates, there appear to be two main mechanisms by which the locations of these double strand breaks are specified: through binding of the gene PRDM9 or by localization to promoter-like features of the genome. I will present our recent work linking these two mechanisms to dramatic differences in the evolutionary dynamics of recombination hotspots, and draw out potential implications for hybridization between closely related species.

Location

Building: BIME (#26)
Room: Auditorium F. Jacob
Address: 28 Rue du Dr Roux, 75015 Paris, France