Projects Project Ongoing 7 Members DNA-binding mechanism and evolution of replication protein A Ludovic Sauguet (PI) Replication Protein A (RPA) is a heterotrimeric single stranded DNA-binding protein with essential roles in DNA replication, recombination and repair. Little is known about the structure of RPA in Archaea, the third domain of […] Project Ongoing 4 Members STRUCTURAL BASIS FOR DNA REPLICATION AND REPLICATION-COUPLED DNA REPAIR IN ARCHAEA Ludovic Sauguet (PI) One fundamental challenge of cells is to accurately copy their genetic material for cell proliferation. DNA replication is performed by sophisticated multi-protein machines, which must synthesize DNA continuously and copy it accurately at the […]
Publications Download 2023 Betancurt-Anzola L, Martínez-Carranza M, Delarue M, Zatopek KM, Gardner AF, Sauguet L, Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases., Nat Commun 2023 Dec; 14(1): 8306. 2023 Madru C, Martínez-Carranza M, Laurent S, Alberti AC, Chevreuil M, Raynal B, Haouz A, Le Meur RA, Delarue M, Henneke G, Flament D, Krupovic M, Legrand P, Sauguet L, DNA-binding mechanism and evolution of replication protein A., Nat Commun 2023 Apr; 14(1): 2326.