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© Uwe Maskos
Tranche d'hippocampe de souris colorée avec deux toxines spécifiques de sous-types de récepteur nicotinique, en rouge (grains), et en vert (corps cellulaires). L'hippocampe est la zone du cerveau qui gère la mémoire spatiale.
Publication : International journal of molecular sciences

Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia.

Team: Integrative Neurobiology of Cholinergic Systems
Member: Uwe Maskos
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal of molecular sciences - 22 Jun 2021

Diabasana Z, Perotin JM, Belgacemi R, Ancel J, Mulette P, Launois C, Delepine G, Dubernard X, Mérol JC, Ruaux C, Gosset P, Maskos U, Polette M, Deslée G, Dormoy V,

Link to Pubmed [PMID] – 34206324

Link to DOI – 665710.3390/ijms22136657

Int J Mol Sci 2021 Jun; 22(13):

The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. The CHRNA5 single-nucleotide polymorphism (SNP) rs16969968 is strongly associated with nicotine dependence and lung diseases. Using immunostaining studies on tissue sections and air-liquid interface airway epithelial cell cultures, in situ hybridisation, transcriptomic and cytokines detection, we analysed rs16969968 contribution to respiratory airway epithelial remodelling and modulation of inflammation. We provide cellular and molecular analyses which support the genetic association of this polymorphism with impaired ciliogenesis and the altered production of inflammatory mediators. This suggests its role in lung disease development.