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© Clifton E. Barry III, Ph.D., NIAID, NIH.
Colorized scanning electron micrograph of Mycobacterium tuberculosis
Publication : EBioMedicine

Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro-American genetic background confers optimal vaccine potential

Team: Integrated Mycobacterial Pathogenomics
Member: Fadel Sayes
Member: Wafa Zouaoui-Frigui
Member: Roland Brosch
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in EBioMedicine - 28 Apr 2020

Pérez I, Uranga S, Sayes F, Frigui W, Samper S, Arbués A, Aguiló N, Brosch R, Martín C, Gonzalo-Asensio J

Link to Pubmed [PMID] – 32361249

Link to DOI – 10.1016/j.ebiom.2020.102761

EBioMedicine 2020 Apr;55:102761

Human tuberculosis (TB) is caused by a plethora of Mycobacterium tuberculosis complex (MTBC) strains belonging to seven phylogenetic branches. Lineages 2, 3 and 4 are considered “modern” branches of the MTBC responsible for the majority of worldwide TB. Since the current BCG vaccine confers variable protection against pulmonary TB, new candidates are investigated. MTBVAC is the unique live attenuated vaccine based on M. tuberculosis in human clinical trials.