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  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
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© Institut Pasteur
Structure de macromolécules : dimère d'aquométhémoglobine de cheval. Dérivé toxique oxydé de l'hémoglobine, représentant 1 à 2% du total.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
20
Feb 2020
Keywords
4 Keywords
Status
Ongoing
Members
3
Structures
1

About

Equilibrium affinity constants (Kd) of protein-protein or protein-ligand interactions can be determined by performing  titrations, and monitoring  the extrinsic or intrinsic fluorescence of partners by Fluorescence spectroscopy (intensity or anisotropy) or by Microscale thermophoresis (LabelFree  or NT-115)

 

SPR (Biacore T200, GE Healthcare,) and BLI (OctetRed384, ForteBio) allow to monitor molecular interactions in real time, and to determine the rates of association (kon) and dissociation (koff) of biomolecular complexes

Isothermal microcalorimetry (VP-ITC and ITC200) enables the thermodynamic characterization of molecular interactions in solution (determination of reaction enthalpy and entropy)

Access Protocol

PFBMI equipments are available for all scientists worldwide, but a priority is given to members of Institut Pasteur and the Institut Pasteur International Network.
Requests can be submitted at any time  (biophysique@pasteur.fr) attaching a project submission form.