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© Research
Publication : Bioinformatics (Oxford, England)

Top-Down Garbage Collector: a tool for selecting high-quality top-down proteomics mass spectra.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bioinformatics (Oxford, England) - 04 Feb 2019

Lima DB, Silva ARF, Dupré M, Santos MDM, Clasen MA, Kurt LU, Aquino PF, Barbosa VC, Carvalho PC, Chamot-Rooke J,

Link to Pubmed [PMID] – 30715205

Link to DOI – 10.1093/bioinformatics/btz085

Bioinformatics 2019 09; 35(18): 3489-3490

We present the first tool for unbiased quality control of top-down proteomics datasets. Our tool can select high-quality top-down proteomics spectra, serve as a gateway for building top-down spectral libraries and, ultimately, improve identification rates.We demonstrate that a twofold rate increase for two E. coli top-down proteomics datasets may be achievable.http://patternlabforproteomics.org/tdgc, freely available for academic use.Supplementary data are available at Bioinformatics online.