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© Research
Publication : Nucleus (Austin, Tex.)

From dynamic chromatin architecture to DNA damage repair and back

Team: Imaging and Modeling
Member: Christophe Zimmer
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nucleus (Austin, Tex.) - 01 Jan 2018

Fabre E, Zimmer C

Link to Pubmed [PMID] – 29271297

Nucleus 2018 Jan;9(1):161-170

Maintaining the integrity of the genome in the face of DNA damage is crucial to ensure the survival of the cell and normal development. DNA lesions and repair occur in the context of the chromatin fiber, whose 3D organization and movements in the restricted volume of the nucleus are under intense scrutiny. Here, we highlight work from our and other labs that addresses how the dynamic organization of the chromatin fiber affects the repair of damaged DNA and how, conversely, DNA damage and repair affect the structure and dynamics of chromatin in the budding yeast nucleus.