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© ALPS team
Publication : Synthetic and systems biotechnology

Norine: A powerful resource for novel nonribosomal peptide discovery

Team: Expertise group : ALPS – Algorithmics and programming in science
Team: Bioinformatics and Biostatistics HUB
Member: Yoann Dufresne
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Synthetic and systems biotechnology - 01 Jun 2016

Pupin M, Esmaeel Q, Flissi A, Dufresne Y, Jacques P, Leclère V

Link to Pubmed [PMID] – 29082924

Synth Syst Biotechnol 2016 Jun;1(2):89-94

Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://bioinfo.lifl.fr/NRP) includes a database now containing more than 1160 annotated peptides and user-friendly interfaces enabling the querying of the database, through the annotations or the structure of the peptides. Dedicated tools are associated for structural comparison of the compounds and prediction of their biological activities. In this paper, we start by describing the knowledgebase and the dedicated tools. We then present some user cases to show how useful Norine is for the discovery of novel nonribosomal peptides.