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Associate Professor
Clinical Research Assistant
Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
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Honorary Professor
Lab assistant
Master Student
Non-permanent Researcher
Nursing Staff
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

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Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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HDR Defense by Sandie Munier

Modeling the Mammalian Microbiota Host Superorganism – www.mam-2018.org

© Institut Pasteur

Phlébotome. Petit diptère de la famille des psychodidés (dans l'Ancien Monde). La femelle hématophage peut être vectrice entre autres de leishmaniose qu'elle transmet par piqûre à un vertébré, chien (hôte principal réservoir), homme ou encore rat (hôtes occasionnels).

Event

“Collateral damage during dengue virus infection: Making sense of DNA by cGAS” with Sebastian Aguirre -Virology department seminar

Team: Viruses and RNA Interference

Department of: Virology

Member: Carla Saleh

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

10

Apr 2018

Time

12:00:00

28 Rue du Docteur Roux, Paris, France

Address

Building: Centre François Jacob

Location

2018-04-10 12:00:00 2018-04-10 13:00:00 Europe/Paris “Collateral damage during dengue virus infection: Making sense of DNA by cGAS” with Sebastian Aguirre -Virology department seminar Sebastian AGUIRRE, PhD Assistant Professor, Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA “Collateral damage during dengue virus infection: Making sense of DNA by cGAS” Mardi 10 Avril […] 28 Rue du Docteur Roux, Paris, France Carla Saleh carla.saleh@pasteur.fr

About

Sebastian AGUIRRE, PhD

Assistant Professor, Department of Microbiology,

Icahn School of Medicine at Mount Sinai, New York, NY, USA

“Collateral damage during dengue virus infection: Making sense of DNA by cGAS”

Mardi 10 Avril 2018 à 12h00

Auditorium Centre François Jacob

Invited by Gonzalo Moratorio (gonzalo.moratorio@pasteur.fr) and Carla Saleh (carla.saleh@pasteur.fr)

Abstract :

For the last decades Dengue virus (DENV) has dramatically increased its global incidence, being now endemic in more than 100 countries. In order to stablish a productive infection in humans, DENV uses different strategies to inhibit or avoid the host innate immune system. Some studies have deciphered mechanisms that rely on viral proteins to strategically target crucial components of the type I IFN system. Here we report that the DNA sensor cGAS is involved in early detection of DENV infection, by recognizing misplaced host DNA. By using biochemical and immunofluorescence techniques, we demonstrate a novel mechanism by which cGAS sense cellular damage upon DENV infection. Furthermore, the NS2B protease co-factor specifically interacts with cGAS during infection and promotes its degradation in a lysosome dependent mechanism. This degradation results in an inhibition of the cGAS/STING cytosolic DNA sensing pathway in primary human dendritic cells.

Location

Building: Centre François Jacob
Address: 28 Rue du Docteur Roux, Paris, France

Published on: 26 Mar 2018 • Modified on: 03 Apr 2018

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