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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Member: Research Engineer

Gabriel Aymé

• Antibody Engineering

Platform: Antibody Engineering
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

Project
Ongoing
3 Members

Advances in cancer immunotherapy development: VHH-based immune checkpoint inhibitors targeting the receptor ILT4

Pierre Lafaye (PI)

ILT4 (immunoglobulin-Like Transcript 4) is an immune checkpoint receptor mainly expressed by myeloid immune cells. In cancer context, ILT4 participates in tumor development by maintaining a pro-tumoral immuno-microenvironment and directly promoting tumor cell proliferation. […]
Project
Ongoing
12 Members

CORONABODIES

Pierre Lafaye (PI)

  CORONABODIES : Production of SARS-CoV-2 nucleoprotein (N) and spike (S) recombinant antigens and generation of anti-N and anti-S VHHs for diagnostic and therapeutic applications. SUMMARY We propose a joint effort to generate as […]
Project
Completed
7 Members

VenoMATIcs: Toward a Global Management of Venoms and Envenomations: the Pasteur network Translational Approach

Balkiss Bouhaouala (PI)

VenoMATIcs’ project aims to strengthen collaborations between Institut Pasteur academic research partners based in 4 MATI regional countries (Morocco, Algeria, Tunisia, Iran), 3 research teams from Institut Pasteur of Paris, in order to use […]
Project
Ongoing
4 Members

Toxins and VHHs as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)

Pierre-Jean Corringer (PI)

Publications

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