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© Institut Pasteur/Marco Gualtieri & Pauline Spéder
News

SEMINAR ” FGFR3 signaling in skeletal development “

Department of: Developmental and Stem Cell Biology
Member: Sigolène Meilhac

Friday 23th September — at 12.00 pm — Salle Monod (Bât.66)

Invited Speaker : Laurence Legeai-Mallet

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From Institut Imagine, INSERM U1163

Hosted by Sigolène Meilhac

Abstract : The Fibroblast Growth Factor Receptors (FGFRs) and their family of ligands (FGF) are required throughout embryonic and postnatal skeletal development. Abnormal FGF signaling causes a spectrum of skeletal disorders. Studies of mice engineered with mutations of Fgfr3 found in patients have provided evidence that many of the developmental functions of FGFR3 signaling are conserved between mouse and human. Our work has also uncovered novel aspects of skeletal growth, mandible development, and cranial suture ossification.