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  • Director of Center
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© Structural Dynamics Of Macromolecules
The structure of a bacterial analog of the nicotinic receptor (one color per subunit) inserted into the cell membrane (grey and orange). A representation of the volume accessible to ions is shown in yellow.
Starting Date
08
Jul 2015
Keywords
7 Keywords
Status
Ongoing
Members
1
Structures
1

About

We study the structure and function of ligand-gated ion channels by X-ray crystallography to understand

  •  i) the gating mechanism (opening of the pore upon agonist binding)
  •  ii) the permeation mechanism (transport of ions through the pore)
  •  iii) modulation by allosteric compounds (general anesthetics, barbiturates…)