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© Research
Publication : Journal of hepatology

Efficient ex vivo gene transfer into non-human primate hepatocytes using HIV-1 derived lentiviral vectors

Team: Innate Immunity
Member: James Di Santo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of hepatology - 02 May 2006

Parouchev A, Nguyen TH, Dagher I, Mainot S, Groyer-Picard MT, Branger J, Gonin P, Di Santo J, Franco D, Gras G, Weber A

Link to Pubmed [PMID] – 16723167

J. Hepatol. 2006 Jul;45(1):99-107

Lentivirus-mediated ex vivo gene therapy is becoming a promising approach for the treatment of liver metabolic disorders. However, the feasibility of this approach needs to be studied in large animal models. The purpose of this study was to evaluate the efficacy of ex vivo gene transfer into Macaca hepatocytes with two different HIV-1 derived lentiviral vectors.