DNA topoisomerase V: a new fold of mysterious origin - Research - Institut Pasteur

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Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon

Crystallization of the C-terminal head domain of the avian adenovirus CELO long fibre.

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Published in Trends in biotechnology - 02 May 2006

Forterre P

Link to Pubmed [PMID] – 16650908

Trends Biotechnol. 2006 Jun;24(6):245-7

Although all other topoisomerases have a broad phylogenetic distribution, DNA topoisomerase V, the major component of the ThermoFidelase sequencing kit, is presently only known in a single species–the archaeon Methanopyrus kandleri. Resolution of the structure of this enzyme by Taneja and co-workers now reveals that this atypical topoisomerase has no structural similarity with other proteins. So, where did it come from? It is my contention that Topo V, and many other orphan proteins, could have a viral origin.

Published on: 02 May 2006