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© Institut Pasteur
Cryptococcus neoformans
Publication : Antimicrobial agents and chemotherapy

Combination of amphotericin B with flucytosine is active in vitro against flucytosine-resistant isolates of Cryptococcus neoformans

Team: RNA Biology of Fungal Pathogens
Team: Fungal Biology and Pathogenicity
Member: Françoise Dromer
Member: Guilhem Janbon
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 16 Oct 2006

Schwarz P, Janbon G, Dromer F, Lortholary O, Dannaoui E

Link to Pubmed [PMID] – 17043122

Antimicrob. Agents Chemother. 2007 Jan;51(1):383-5

The combination of flucytosine and amphotericin B was tested against 10 flucytosine-resistant isolates of Cryptococcus neoformans by checkerboard, killing curves, and Etest. Although differences were observed depending on the technique used, antagonism was never observed. The synergistic interaction was related to the mechanism of flucytosine resistance of the isolates.