C2RT Seminar - Research - Institut Pasteur

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SaMMBA seminar: Thibaut Morel-Journel (Sorbonne Paris Nord, Paris Cité, Inserm)

Explore Funding Opportunities in the Origins of Diseases and Health & Disease at the Extremes of Life – Strategic Plan Pasteur 2030 Priorities 3 & 4

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

22

Oct 2025

Time

10:30:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

Address

Building: 26 Room: Auditorium F. Jacob

Location

2025-10-22 10:30:00 2025-10-22 12:00:00 Europe/Paris C2RT Seminar Auditorium F. Jacob – 10:30am Photoresponsive Cell Achoring Surfaces for Single-Cell Phenotypic Imaging Prof. S. Yamaguchi Professor at Department of Synthetic Chemistry for Molecular SystemsSANKEN, The University of Osaka Until now, the mechanisms by […] Institut Pasteur, Rue du Docteur Roux, Paris, France Florian Muller florian.muller@pasteur.fr

Speakers

Satoshi Yamaguchi

(Department of Synthetic Chemistry for Molecular Systems SANKEN, The University of Osaka)

About

Auditorium F. Jacob – 10:30am

Photoresponsive Cell Achoring Surfaces for Single-Cell Phenotypic Imaging

Prof. S. Yamaguchi

Professor at Department of Synthetic Chemistry for Molecular Systems
SANKEN, The University of Osaka

Until now, the mechanisms by which immune cells exert cytotoxic effects on cancer cells have been evaluated solely based on average values across entire cell populations. As a result, it has been challenging to obtain information about rare cancer cells that evade immune attack or rare immune cells with exceptionally high cytotoxic activity against cancer cells. To address these challenges, we developed a dual-cell measurement technology that employs a photoactivatable cell-anchoring surface to position single immune cells and single cancer cells adjacent to each other on a substrate, thereby enabling comprehensive analysis of their interactions at the single-cell level. For example, classification of the time-lapse imaging data using machine learning revealed the presence of NK cells that induced either apoptosis-like or necrosis-like cell death. Thus, this dual-cell measurement technology represents a promising platform for immune diagnostics, therapeutic cell discovery, and quality control of CAR-T cells. In this seminar, I would also like to provide a detailed introduction to our original photoresponsive cell-anchoring surfaces, including their development history, the unique mechanism of cell attachment and other application studies.

For any questions email: florian.muller@pasteur.fr and maria-isabella.gariboldi@pasteur.fr

Seminar_Yamaguchi Download

Location

Building: 26
Room: Auditorium F. Jacob
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 29 Sep 2025 • Modified on: 08 Oct 2025

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