Timeline

Nathalie Barilone

Technician

25 Sep 2023

publication

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.

25 May 2023

publication

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

23 Oct 2020

publication

The desensitization pathway of GABAA receptors, one subunit at a time.

29 Jan 2017

publication

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

18 Jun 2015

publication

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

11 May 2015

team

Membrane Traffic and Pathogenesis

11 May 2015

team

Biology of infection

25 Mar 2015

publication

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.

17 Nov 2014

publication

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

21 Sep 2014

team

Channel Receptors

03 May 2012

publication

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

28 Oct 2010

publication

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis

01 Jun 2010

publication

Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic

04 Aug 2009

publication

AftD, a novel essential arabinofuranosyltransferase from mycobacteria

18 Sep 2008

publication

Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice

01 Jan 2008

publication

Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics

19 Jul 2007

publication

Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis

01 Jan 2007

publication

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis

15 Sep 2006

publication

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

30 May 2006

publication

Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives

02 Dec 2005

publication

The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis

06 Oct 2005

publication

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Timeline

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.

The desensitization pathway of GABAA receptors, one subunit at a time.

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

Membrane Traffic and Pathogenesis

Biology of infection

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

Channel Receptors

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis

Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic

AftD, a novel essential arabinofuranosyltransferase from mycobacteria

Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice

Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics

Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives

The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis

p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis