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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Publication : The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Rapid identification of multidrug-resistant tuberculosis isolates in treatment failure or relapse patients in Bangui, Central African Republic

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 01 Jun 2010

Minime-Lingoupou F, Pierre-Audigier C, Kassa-Kélémbho E, Barilone N, Zandanga G, Rauzier J, Cadet-Daniel V, Le Faou A, Gicquel B

Link to Pubmed [PMID] – 20487620

Int. J. Tuberc. Lung Dis. 2010 Jun;14(6):782-5

Multidrug-resistant (MDR) strains were identified in 40% of 54 strains from patients presenting with tuberculosis (TB) treatment failure or relapse in Bangui, Central African Republic. Results obtained with the MTBDRplus line-probe assay or rpoB sequencing were 86% concordant with rifampicin (RMP) resistant phenotypes, while the amplification refractory mutation system test was 71% concordant. No mutation was found in RMP-susceptible strains. MTBDRplus and sequencing were concordant with the detection of the S315T mutation in katG in 95% of MDR strains. Sequencing of pncA suggested pyrazinamide resistance in 50% of MDR strains. Knowledge of these resistances should help to implement treatment in low-income countries.

https://www.ncbi.nlm.nih.gov/pubmed/20487620