Lien vers Pubmed [PMID] – 30715205
Lien DOI – 10.1093/bioinformatics/btz085
Bioinformatics 2019 09; 35(18): 3489-3490
We present the first tool for unbiased quality control of top-down proteomics datasets. Our tool can select high-quality top-down proteomics spectra, serve as a gateway for building top-down spectral libraries and, ultimately, improve identification rates.We demonstrate that a twofold rate increase for two E. coli top-down proteomics datasets may be achievable.http://patternlabforproteomics.org/tdgc, freely available for academic use.Supplementary data are available at Bioinformatics online.