Lien vers Pubmed [PMID] – 36931922
Lien DOI – 10.1016/j.pt.2023.03.003
Trends Parasitol 2023 May; 39(5): 319-320
Productive invasion of hepatocytes by Plasmodium sporozoites is a key step of infection. The parasites traverse hepatocytes before targeting one of them to form a parasitophorous vacuole for parasite expansion. Schepis et al. show the induction of membrane ruffling via host Rho GTPases by Plasmodium sporozoites facilitating productive invasion.