• 2023
  Clément DA, Gelin M, Leseigneur C, Huteau V, Mondange L, Pons JL, Dussurget O, Lionne C, Labesse G, Pochet S, , Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria., Eur J Med Chem 2023 Jan; 246(): 114941.
• 2022
  Rahimova R, Nogaret P, Huteau V, Gelin M, Clément DA, Labesse G, Pochet S, Blanc-Potard AB, Lionne C, , Structure-based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase., FEBS J 2022 Aug; (): .
• 2021
  Pezo V, Jaziri F, Bourguignon PY, Louis D, Jacobs-Sera D, Rozenski J, Pochet S, Herdewijn P, Hatfull GF, Kaminski PA, Marliere P, , Noncanonical DNA polymerization by aminoadenine-based siphoviruses., Science 2021 04; 372(6541): 520-524.
• 2020
  Clément DA, Leseigneur C, Gelin M, Coelho D, Huteau V, Lionne C, Labesse G, Dussurget O, Pochet S, , New Chemical Probe Targeting Bacterial NAD Kinase., Molecules 2020 Oct; 25(21): .
• 2020
  Gelin M, Paoletti J, Nahori MA, Huteau V, Leseigneur C, Jouvion G, Dugué L, Clément D, Pons JL, Assairi L, Pochet S, Labesse G, Dussurget O, , From Substrate to Fragments to Inhibitor Active In Vivo against Staphylococcus aureus., ACS Infect Dis 2020 Mar; 6(3): 422-435.
• 2020
  Vichier-Guerre S, Ku T, Pochet S, Seley-Radtke KL, An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases, Chembiochem 2020 Jan;.
• 2019
  Reolon LW, Vichier-Guerre S, de Matos BM, Dugué L, Assunção TRDS, Zanchin NIT, Pochet S, Guimarães BG, Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4, Nucleic Acids Res. 2019 Jun;47(11):5973-5987.
• 2019
  Vichier-Guerre S, Dugué L, Pochet S, 2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates, Org. Biomol. Chem. 2019 01;17(2):290-301.
• 2018
  Randrianjatovo-Gbalou I, Rosario S, Sismeiro O, Varet H, Legendre R, Coppée JY, Huteau V, Pochet S, Delarue M, Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries, Nucleic Acids Res. 2018 07;46(12):6271-6284.
• 2017
  S. Vichier-Guerre, L. Dugué, F. Bonhomme and S. Pochet, An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles, Org. Biomol. Chem., 2017, 15, 8193.
• 2016
  Paoletti J, Assairi L, Gelin M, Huteau V, Nahori MA, Dussurget O, Labesse G, Pochet S, , 8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode., Eur J Med Chem 2016 Nov; 124(): 1041-1056.
• 2016
  S. Vichier-Guerre, L. Dugué, F. Bonhomme and S. Pochet, Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation, Org. Biomol. Chem., 2016, 14, 3638.
• 2015
  Claire Amiable and Sylvie Pochet, Unprecedented formation of 8(R),5′-O-cycloribonucleosides through a triflation reaction of purine ribonucleosides, Tetrahedron, 71, 2525-2529..
• 2014
  Sophie Vichier-Guerre, Laurence Dugué and Sylvie Pochet, A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction, Tetrahedron Lett. 2014; 55(46);6347–6350.
• 2014
  Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S, 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities, Eur J Med Chem 2014 Oct;85:418-37.
• 2014
  Laurence Morellato, Valérie Huteau and Sylvie Pochet, Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction, Tetrahedron Letters 02/2014; 55(9):1625–1627. .
• 2013
  Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA, N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1, PLoS ONE 2013;8(11):e80755.
• 2013
  Padilla A, Amiable C, Pochet S, Kaminski PA, Labesse G, Structure of the oncoprotein Rcl bound to three nucleotide analogues, Acta Crystallogr. D Biol. Crystallogr. 2013 Feb;69(Pt 2):247-55.
• 2012
  Gelin M, Poncet-Montange G, Assairi L, Morellato L, Huteau V, Dugué L, Dussurget O, Pochet S, Labesse G, , Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound., Structure 2012 Jun; 20(6): 1107-17.
• 2012
  Van Calenbergh S, Pochet S, Munier-Lehmann H, Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase, Curr Top Med Chem 2012;12(7):694-705.
• 2011
  le Maire A, Gelin M, Pochet S, Hoh F, Pirocchi M, Guichou JF, Ferrer JL, Labesse G, In-plate protein crystallization, in situ ligand soaking and X-ray diffraction, Acta Crystallogr. D Biol. Crystallogr. 2011 Sep;67(Pt 9):747-55.
• 2010
  Dupouy C, Zhang C, Padilla A, Pochet S, Kaminski PA, Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108, J. Biol. Chem. 2010 Dec;285(53):41806-14.
• 2008
  Caillat C, Topalis D, Agrofoglio LA, Pochet S, Balzarini J, Deville-Bonne D, Meyer P, Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy, Proc. Natl. Acad. Sci. U.S.A. 2008 Nov;105(44):16900-5.
• 2008
  Kaminski PA, Dacher P, Dugué L, Pochet S, In vivo reshaping the catalytic site of nucleoside 2′-deoxyribosyltransferase for dideoxy- and didehydronucleosides via a single amino acid substitution, J. Biol. Chem. 2008 Jul;283(29):20053-9.
• 2008
  Gasse C, Douguet D, Huteau V, Marchal G, Munier-Lehmann H, Pochet S, Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity, Bioorg. Med. Chem. 2008 Jun;16(11):6075-85.
• 2008
  Kaminski PA, Dugué L, Pochet S, Expanding substrate specificity of nucleoside 2′-deoxyribosyltransferase, Nucleic Acids Symp Ser (Oxf) 2008;(52):495-6.
• 2007
  Poncet-Montange G, Assairi L, Arold S, Pochet S, Labesse G, NAD kinases use substrate-assisted catalysis for specific recognition of NAD, J. Biol. Chem. 2007 Nov;282(47):33925-34.
• 2007
  Alexandre JA, Roy B, Topalis D, Pochet S, Périgaud C, Deville-Bonne D, Enantioselectivity of human AMP, dTMP and UMP-CMP kinases, Nucleic Acids Res. 2007;35(14):4895-904.
• 2007
  Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D, Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site, FEBS J. 2007 Jul;274(14):3704-14.
• 2007
  Gasse C, Huteau V, Douguet D, Munier-Lehmann H, Pochet S, A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, Nucleosides Nucleotides Nucleic Acids 2007;26(8-9):1057-61.
• 2007
  Topalis D, Kumamoto H, Alexandre JA, Dugué L, Pochet S, Berteina-Raboin S, Agrofoglio LA, Deville-Bonne D, Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase, Nucleosides Nucleotides Nucleic Acids 2007;26(10-12):1369-73.
• 2007
  Moriou C, Thomas M, Adeline MT, Martin MT, Chiaroni A, Pochet S, Fourrey JL, Favre A, Clivio P, Crystal structure and photochemical behavior in solution of the 3′-N-sulfamate analogue of thymidylyl(3′-5′)thymidine, J. Org. Chem. 2007 Jan;72(1):43-50.
• 2006
  Kamiya H, Cadena-Amaro C, Dugué L, Yakushiji H, Minakawa N, Matsuda A, Pochet S, Nakabeppu Y, Harashima H, Recognition of nucleotide analogs containing the 7,8-dihydro-8-oxo structure by the human MTH1 protein, J. Biochem. 2006 Dec;140(6):843-9.
• 2005
  Topalis D, Collinet B, Gasse C, Dugué L, Balzarini J, Pochet S, Deville-Bonne D, Substrate specificity of vaccinia virus thymidylate kinase, FEBS J. 2005 Dec;272(24):6254-65.
• 2005
  Douguet D, Munier-Lehmann H, Labesse G, Pochet S, LEA3D: a computer-aided ligand design for structure-based drug design, J. Med. Chem. 2005 Apr;48(7):2457-68.
• 2005
  Volmer R, Bajramovic JJ, Schneider U, Ufano S, Pochet S, Gonzalez-Dunia D, Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus, J. Virol. 2005 Apr;79(7):4514-8.
• 2005
  Cadena-Amaro C, Delepierre M, Pochet S, Synthesis and incorporation into DNA fragments of the artificial nucleobase, 2-amino-8-oxopurine, Bioorg. Med. Chem. Lett. 2005 Feb;15(4):1069-73.
• 2004
  Suspène R, Sommer P, Henry M, Ferris S, Guétard D, Pochet S, Chester A, Navaratnam N, Wain-Hobson S, Vartanian JP, APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase, Nucleic Acids Res. 2004;32(8):2421-9.
• 2004
  Bajramovic JJ, Volmer R, Syan S, Pochet S, Gonzalez-Dunia D, 2′-fluoro-2′-deoxycytidine inhibits Borna disease virus replication and spread, Antimicrob. Agents Chemother. 2004 Apr;48(4):1422-5.
• 2004
  Kamiya H, Yakushiji H, Dugué L, Tanimoto M, Pochet S, Nakabeppu Y, Harashima H, Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs, J. Mol. Biol. 2004 Feb;336(4):843-50.
• 2003
  Pochet S, Kaminski PA, Van Aerschot A, Herdewijn P, Marlière P, Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo, C. R. Biol. 2003 Dec;326(12):1175-84.
• 2003
  Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2003 Sep;13(18):3045-8.
• 2003
  Vanheusden V, Munier-Lehmann H, Froeyen M, Dugué L, Heyerick A, De Keukeleire D, Pochet S, Busson R, Herdewijn P, Van Calenbergh S, 3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, J. Med. Chem. 2003 Aug;46(18):3811-21.
• 2003
  Pochet S, Dugué L, Labesse G, Delepierre M, Munier-Lehmann H, Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans, Chembiochem 2003 Aug;4(8):742-7.
• 2003
  Munier-Lehmann H, Pochet S, Dugue L, Dutruel O, Labesse G, Douget D, Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):801-4.
• 2003
  Pochet S, Dugué L, Strobel H, Synthesis and recognition by DNA polymerases of a reactive nucleoside for DNA diversification, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1665-7.
• 2003
  Lagoja IM, Pochet S, Boudou V, Little R, Lescrinier E, Rozenski J, Herdewijn P, A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides, J. Org. Chem. 2003 Mar;68(5):1867-71.
• 2002
  Strobel H, Dugué L, Marlière P, Pochet S, A parallel synthesis scheme for generating libraries of DNA polymerase substrates and inhibitors, Chembiochem 2002 Dec;3(12):1251-6.
• 2002
  Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2002 Oct;12(19):2695-8.
• 2002
  Strobel H, Dugué L, Marlière P, Pochet S, Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide, Nucleic Acids Res. 2002 May;30(9):1869-78.
• 2002
  Pochet S, Dugue L, Douguet D, Labesse G, Munier-Lehmann H, Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications, Chembiochem 2002 Jan;3(1):108-10.
• 2002
  Kamiya H, Dugué L, Yakushiji H, Pochet S, Nakabeppu Y, Harashima H, Substrate recognition by the human MTH1 protein, Nucleic Acids Res. Suppl. 2002;(2):85-6.
• 2001
  Vastmans K, Froeyen M, Kerremans L, Pochet S, Herdewijn P, Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides, Nucleic Acids Res. 2001 Aug;29(15):3154-63.
• 2001
  Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G, Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes, Protein Sci. 2001 Jun;10(6):1195-205.
• 2000
  Vastmans K, Pochet S, Peys A, Kerremans L, Van Aerschot A, Hendrix C, Marlière P, Herdewijn P, Enzymatic incorporation in DNA of 1,5-anhydrohexitol nucleotides, Biochemistry 2000 Oct;39(42):12757-65.
• 1999
  Pistotnik E, Sakamoto H, Pochet S, Namane A, Bârzu O, Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system, Anal. Biochem. 1999 Jul;271(2):192-3.
• 1996
  Sala M, Pezo V, Pochet S, Wain-Hobson S, Ambiguous base pairing of the purine analogue 1-(2-deoxy-beta-D-ribofuranosyl)-imidazole-4-carboxamide during PCR, Nucleic Acids Res. 1996 Sep;24(17):3302-6.
• 1996
  Pochet S, Marlière P, Construction of a self-complementary nucleoside from deoxyguanosine, C. R. Acad. Sci. III, Sci. Vie 1996 Jan;319(1):1-7.
• 1994
  Mazel D, Pochet S, Marlière P, Genetic characterization of polypeptide deformylase, a distinctive enzyme of eubacterial translation, EMBO J. 1994 Feb;13(4):914-23.
• 1993
  Richaud C, Mengin-Lecreulx D, Pochet S, Johnson EJ, Cohen GN, Marlière P, Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli, J. Biol. Chem. 1993 Dec;268(36):26827-35.
• 1990
  Pochet S, D'Ari R, Synthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide-5′- triphosphate, Nucleic Acids Res. 1990 Dec;18(23):7127-31.
• 1989
  Arcangioli B, Pochet S, Sousa R, Huynh-Dinh T, Preparation and use of a universal primed Sepharose for the purification of DNA-binding proteins, Eur. J. Biochem. 1989 Feb;179(2):359-63.
• 1988
  Adam S, Ridoux JP, Bourtayre P, Taillandier E, Pochet S, Huynh-Dinh T, Igolen J, IR and UV studies on stability and conformations of short DNA duplexes containing a no-base residue: coexistence of B and Z conformations, J. Biomol. Struct. Dyn. 1988 Aug;6(1):167-79.
• 1988
  Pochet S, Arcangioli B, Huynh-Dinh T, Solid-supported ligation primer, Nucleic Acids Res. 1988 Feb;16(4):1619.
• 1986
  Pochet S, Huynh-Dinh T, Neumann JM, Tran-Dinh S, Adam S, Taboury J, Taillandier E, Igolen J, NMR, CD and IR spectroscopies of a tridecanucleotide containing a no-base residue: coexistence of B and Z conformations, Nucleic Acids Res. 1986 Jan;14(2):1107-26.