Biological study of secreted dengue virus nonstructural protein NS1
Flavivirus NS1 is involved in the intracellular stages of virus replication. It also circulates in the extracellular medium although its related function remains unknown. We have developed a dengue diagnostic kit based on the NS1 antigen capture by ELISA that has become a reference in the field since its commercialization by BioRad in 2006. We are currently pursuing the functional characterization of the secreted form of dengue virus NS1 in an attempt to specify its contribution to fatal hemorrhagic fevers.