Salmonella enterica infections in humans are responsible for three major clinical syndromes, typhoid fever caused by host-specific Salmonella, a diarrheal disease known as salmonellosis caused by several non-typhoidal Salmonella (NTS) and invasive NTS (iNTS) infection with bacteremia in immunocompromised patients. Salmonellosis is one of the most common and widely distributed food-borne diseases in Europe and North
America, in particular by ingestion of contaminated poultry products. Mouse models have been used to study distinct aspects of the human Salmonella infection in vivo and have led to the identification of susceptibility genes. We are assessing the range of responses of Collaborative Cross mice to infection with Salmonella Typhimurium (a model of human typhoid fever) and Salmonella Enteritidis (a model of salmonellosis). Using QTL mapping approches, we have identified several novel susceptibility loci andwe are progressing towards the identification of the causal genetic variants.