Thierry Lang

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Academic Qualifications

• 1983: DEA d’Immunologie Approfondie Paris 7
• 1987: Doctorat de Microbiologie l’Université Paris 7 (equivalent to PhD)
• 2005 : Diplôme d’Habilitation à Diriger des Recherches (HDR) Paris 5

Position

• Fellow of the Fondation Roux (1987-1988).
• Assistant (1989-1995) at the Pasteur Institute in the Electron Microscopy       Unit (head of the Unit : Pr A. Ryter).
• Posdoctoral Research Fellow (1989-1991) at the London School of Hygiene and Tropical Medicine in the Immunobiology of Parasitic Diseases Unit of the Department of Medical Parasitology (head of the Unit: Pr J. Blackwell).
• Chargé de recherche at the Pasteur Institute:

-1996-1998 in the Cellular Immunophysiology Unit (head of the Unit: Pr R. Fauve).

-1998- oct 2012 in the Immunophysiology and Intracellular Parasitism Unit of the Department of Parasitology (head of the Unit: Dr. G. Milon).

-Since Nov 2012 in the Laboratory of Trypanosomatids Infectious Process (head of the Laboratory: Dr P.Minoprio

Professional activities :

               Teaching

• 2000-2006 Supervision of practical work on the immune response induced by the parasites Leishmania (Pasteur Institute, Paris).
• University Lectures – Pierre et Marie Curie -Paris VI (2005-2010) :

Parasitologie/Mycologie Fondamentale et Médicale : Biologie Moléculaire et cellulaire des agents infectieux et de la cellule hôte.

Interactions Système Immunitaire et Parasites 2010-2013

Major Research Interests 1988-2015

• Endocytosis in macrophages.
• Parasitic processes in mice intradermally inoculated into the ears with L. major or L. amazonensis metacyclic
• Bioluminescent Leishmania major in living C57Bl/6 mice: reliable probes for analysing the concomitant immunity-related processes.
• Long term follow up of Leishmania amazonensis load in C57Bl/6 and DBA/2 mice using bioluminescence imaging in combination with real-time PCR.
• Gene expression profiling of mouse mononuclear phagocytes harbouring Leishmania amazonensis amastigotes. Comparative studies on dendritic leucocytes from either susceptible or resistant mice.
• Lipid metabolism in mouse dendritic leucocytes hosting live Leishmania amazonensis amastigotes.
• Generation and validation of innovative tools for 2D- and 3D-real time imaging of trypanosomatid parasites in their mammalian host.
• Real time imaging of L. donovani in rodents