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Functional characterization of mosquito genes involved in dengue virus transmission identified by RNA-seq at the individual midgut level
Louis Lambrechts (PI)
Dengue is the most rapidly expanding, globally dominant arthropod-borne (arbo) viral disease. It affects close to 400 million people each year in more than 125 countries. Recent reports of autochtonous cases in Southern France […]
2010-2015 PhD Degree in Virology and Immunology Radboud Institute for Molecular Life Sciences Department of Medical Microbiology Radboud University, Nijmegen, The Netherlands 2008-2010 Master Degree in Molecular Biology, Cell Biology and Immunology Université de Strasbourg, France 2005-2008 Bachelor Degree in Cell Biology and Physiology Université de Strasbourg, France
Since November 2020 CNRS permanent researcher within the Interactions Virus-Insect Unit, Institut Pasteur, CNRS UMR 2000. December 2015-October 2020 Post-doctoral researcher Institut Pasteur, Paris, France Supervisor: Dr. Louis Lambrechts Topic: Functional genomics of dengue virus transmission by Aedes mosquitoes. December 2010-September 2015 PhD student Radboud University Medical Center, Nijmegen, The Netherlands Supervisor: Dr. Ronald van Rij Topic: Antiviral resistance and tolerance in Drosophila July 2009-July 2010 2nd Master apprenticeship Institute of Cellular and Molecular Biology (IBMC), Strasbourg, France Supervisors: Pr. Jules Hoffmann and Dr. Hidehiro Fukuyama Topic: Immunity against Alzheimer’s disease in Drosophila January-June 2010 1st Master apprenticeship IBMC, Strasbourg, France Supervisor: Pr. Sylvie Fournel Topic: B-cell immune modulation with CD40-like synthetic ligands July-August 2009 Bachelor apprenticeship IBMC, Strasbourg, France Supervisors: Pr. Jean-Marc Reichhart and Dr. Vincent Leclerc Topic: Antibacterial defense in Drosophila
Fellowships and Awards
2020 Labex IBEID Springboard to Independence ANR Grant 2018 L’Oréal-UNESCO For Women in Science Award 2018 ACME Young Investigator Travel Award 2018 Best Oral Presentation Award Virology day, Institut Pasteur, Paris 2017 Pasteur-Roux Post-doctoral Fellowship Grant 2016 Seal of excellence (Certificate delivered by the European Commission for a high-quality Horizon 2020 Marie Sklodowska-Curie application rated with 92% score) 2014 Radboud University internationalization travel grant for the attendance of the 55th Annual Drosophila Research Conference, San Diego, USA 2013 Best Poster Award Symposium on Integrated Immunology, Pulstuk, Poland 2012 Erasmus training travel grant for attendance of Drosophila Genetics and Genomics course, Cambridge, UK
Independent Coursework and training
2019 Single-cell sequencing technologies, Institut Pasteur, Paris, France 2018 Leadership training form Women in Science, CEDEP, Fontainebleau, France 2017 EMBO Laboratory Management and Leadership Course, Heidelberg, Germany 2016 RNA sequencing and transcriptomics, Institut Pasteur, Paris, France 2016 Statistics in R, Institut Pasteur, Paris, France 2014 Academic writing, Radboud University, Nijmegen, NL 2013 The art of presenting science, Radboud University, Nijmegen, NL 2012 Drosophila genetics and genomics, University of Cambridge, UK
2018 67th American Society for Tropical Medicine and Hygiene, New Orleans, USA 2017 LabEx IBEID 7th Annual Meeting, Paris, France 2014 55th Annual Drosophila Research Conference, San Diego, USA 2014 Annual Dutch Virology Symposium, Amsterdam, NL 2013 Chemistry in Biology and Medical research,Veldhoven, NL 2012 Drosophila Genetics and Genomics, Cambridge, UK
2019 CNRS J.Monod Conference “Integrated insect immunology: controlling infections” – Roscoff, France 2019 Keystone Meeting “Positive-Strand RNA Viruses”, Killarney, Ireland 2017 EMBO Meeting – Molecular and Population Biology of Mosquitoes and other Disease Vectors, Kolymbari, Greece 2015 International Meeting on Arboviruses and their Vectors, Glasgow, UK 2013 Symposium on integrated Insect Immunology, Pulstuk, Poland
2016-2017 Scientific manager of the BSL-3/Insectary facility at Institut Pasteur, Paris, France
Science communication and public outreach
2018 L’Oréal-UNESCO ambassadress communication events: Press interviews and TV recordings for French local and national press, dissemination of science on social media (Facebook, Twitter, Instagram) 2017 Scientific “speed-dating” with high-school students from Lycée Paul Bert in Paris with the “Déclics 2017” program 2016 Supervision of 2 high-school students for a small scientific project within the “Apprentis Chercheurs” initiative at Institut Pasteur Since 2011 Science communication to scientists and general public via Twitter (@Drosophilista, >1100 followers)
2021Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection., Nat Immunol 2021 Sep; (): .
2021Kinetics of the SARS-CoV-2 antibody response and serological estimation of time since infection., J Infect Dis 2021 Jul; (): .
2021Multiplex assays for the identification of serological signatures of SARS-CoV-2 infection: an antibody-based diagnostic and machine learning study., Lancet Microbe 2021 Feb; 2(2): e60-e69.
2020Enhanced Zika virus susceptibility of globally invasive Aedes aegypti populations., Science 2020 11; 370(6519): 991-996.
2020Non-retroviral Endogenous Viral Element Limits Cognate Virus Replication in Aedes aegypti Ovaries., Curr Biol 2020 09; 30(18): 3495-3506.e6.
2020Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients., Science 2020 08; 369(6504): 718-724.
2020Exome-wide association study reveals largely distinct gene sets underlying specific resistance to dengue virus types 1 and 3 in Aedes aegypti., PLoS Genet 2020 05; 16(5): e1008794.
2020A satellite repeat-derived piRNA controls embryonic development of Aedes., Nature 2020 04; 580(7802): 274-277.
2020Tudor-SN Promotes Early Replication of Dengue Virus in the Aedes aegypti Midgut., iScience 2020 Feb; 23(2): 100870.
2020Taking Insect Immunity to the Single-Cell Level., Trends Immunol 2020 03; 41(3): 190-199.
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