Nick Owens studied Computer science at the University of York, UK, for both undergraduate and PhD in Biologically Inspired Algorithms/Machine Learning. He moved to Mike Gilchrist’s lab at the Francis Crick Institute, London, UK (formerly MRC National Institute for Medical Research) to work on gene regulation in early Xenopus development. He then moved to Pablo Navarro’s lab at Institut Pasteur. Here, he applies computational methods to understand transcription factor binding and nucleosome positioning in mouse embryonic stem cells.
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2022OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency., Nucleic Acids Res 2022 07; 50(13): 7367-7379.
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2020Compensation between Wnt-driven tumorigenesis and cellular responses to ribosome biogenesis inhibition in the murine intestinal epithelium, Cell Death Differ. 2020 Apr;.
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2019Transcription factor activity and nucleosome organization in mitosis., Genome Res 2019 02; 29(2): 250-260.
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2017Mitotic bookmarking in development and stem cells, Development 2017 10;144(20):3633-3645.
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2017Esrrb, an estrogen-related receptor involved in early development, pluripotency, and reprogramming, FEBS Lett. 2018 03;592(6):852-877.