Mathieu Mateo

Focus on hemorrhagic fever viruses, host/pathogen interactions, viral countermeasures, vaccines

Education 2001-2003  DEUG in Life and Earth Sciences, UCBL1 2003-2004  Licence in Molecular and Cellular Biology, ENS Lyon 2004-2006  Master in Molecular and Cellular Biology, ENS Lyon 2006-2010  Ph.D. thesis, ENS Lyon Professional positions Sep 2006 – Dec 2010  Ph.D. student, Microbiology/ Molecular Virology, ENS Lyon (Viktor Volchkov’s lab) Mar 2008 – Aug 2008  Visiting Ph.D. student, Microbiology Dpt, Mount Sinai School of Medicine, New York City  (Christopher Basler’s lab) Jan 2011 – Feb 2011  Postdoctoral fellow, Microbiology/ Molecular Virology, , ENS Lyon (Viktor Volchkov’s lab) Mar 2011 – Oct 2014 Postdoctoral fellow, Molecular Medicine, Mayo Clinic, Rochester, Minnesota (Roberto Cattaneo’s lab) Nov 2014 – Dec 2016 Postdoctoral fellow, UBIVE, Institut Pasteur, Lyon (Sylvain Baize’s lab) Since Jan 2017  Chargé de recherche, UBIVE, Institut Pasteur, Lyon (Sylvain Baize’s lab) Publications

1. Reynard O, Borowiak M, Volchkova VA, Delpeut S, Mateo M, Volchkov VE. Ebolavirus glycoprotein GP masks both its own epitopes and the presence of cellular surface proteins. Journal of virology. 2009;83(18):9596-601. doi: 10.1128/JVI.00784-09. PubMed PMID: 19587051; PMCID: 2738224.
2. Mateo M, Reid SP, Leung LW, Basler CF, Volchkov VE. Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling. Journal of virology. 2010;84(2):1169-75. doi: 10.1128/JVI.01372-09. PubMed PMID: 19889762; PMCID: 2798383.
3. Mateo M, Carbonnelle C, Martinez MJ, Reynard O, Page A, Volchkova VA, Volchkov VE. Knockdown of Ebola virus VP24 impairs viral nucleocapsid assembly and prevents virus replication. The Journal of infectious diseases. 2011;204 Suppl 3:S892-6. doi: 10.1093/infdis/jir311. PubMed PMID: 21987766.
4. Mateo M, Carbonnelle C, Reynard O, Kolesnikova L, Nemirov K, Page A, Volchkova VA, Volchkov VE. VP24 is a molecular determinant of Ebola virus virulence in guinea pigs. The Journal of infectious diseases. 2011;204 Suppl 3:S1011-20. doi: 10.1093/infdis/jir338. PubMed PMID: 21987737.
5. Muhlebach MD, Mateo M, Sinn PL, Prufer S, Uhlig KM, Leonard VH, Navaratnarajah CK, Frenzke M, Wong XX, Sawatsky B, Ramachandran S, McCray PB, Jr., Cichutek K, von Messling V, Lopez M, Cattaneo R. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature. 2011;480(7378):530-3. doi: 10.1038/nature10639. PubMed PMID: 22048310; PMCID: 3245798.
6. Reynard O, Mokhonov V, Mokhonova E, Leung J, Page A, Mateo M, Pyankova O, Georges-Courbot MC, Raoul H, Khromykh AA, Volchkov VE. Kunjin virus replicon-based vaccines expressing Ebola virus glycoprotein GP protect the guinea pig against lethal Ebola virus infection. The Journal of infectious diseases. 2011;204 Suppl 3:S1060-5. doi: 10.1093/infdis/jir347. PubMed PMID: 21987742; PMCID: 3189994.
7. Reynard O, Nemirov K, Page A, Mateo M, Raoul H, Weissenhorn W, Volchkov VE. Conserved proline-rich region of Ebola virus matrix protein VP40 is essential for plasma membrane targeting and virus-like particle release. The Journal of infectious diseases. 2011;204 Suppl 3:S884-91. doi: 10.1093/infdis/jir359. PubMed PMID: 21987765.
8. Reynard O, Reid SP, Page A, Mateo M, Alazard-Dany N, Raoul H, Basler CF, Volchkov VE. Unconventional secretion of Ebola virus matrix protein VP40. The Journal of infectious diseases. 2011;204 Suppl 3:S833-9. doi: 10.1093/infdis/jir305. PubMed PMID: 21987759; PMCID: 3189981.
9. Mateo M, Lopez M. [Nectin-4, a key factor for measles virus host exit]. Medecine sciences : M/S. 2012;28(4):363-5. doi: 10.1051/medsci/2012284010. PubMed PMID: 22549860.
10. Frenzke M, Sawatsky B, Wong XX, Delpeut S, Mateo M, Cattaneo R, von Messling V. Nectin-4-dependent measles virus spread to the cynomolgus monkey tracheal epithelium: role of infected immune cells infiltrating the lamina propria. Journal of virology. 2013;87(5):2526-34. doi: 10.1128/JVI.03037-12. PubMed PMID: 23255790; PMCID: 3571369.
11. Mateo M, Navaratnarajah CK, Syed S, Cattaneo R. The measles virus hemagglutinin beta-propeller head beta4-beta5 hydrophobic groove governs functional interactions with nectin-4 and CD46 but not those with the signaling lymphocytic activation molecule. Journal of virology. 2013;87(16):9208-16. doi: 10.1128/JVI.01210-13. PubMed PMID: 23760251; PMCID: 3754078.
12. Mateo M, Navaratnarajah CK, Cattaneo R. Structural basis of efficient contagion: measles variations on a theme by parainfluenza viruses. Current opinion in virology. 2014;5:16-23. doi: 10.1016/j.coviro.2014.01.004. PubMed PMID: 24492202; PMCID: 4028398.
13. Mateo M, Navaratnarajah CK, Willenbring RC, Maroun JW, Iankov I, Lopez M, Sinn PL, Cattaneo R. Different roles of the three loops forming the adhesive interface of nectin-4 in measles virus binding and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1. Journal of virology. 2014;88(24):14161-71. doi: 10.1128/JVI.02379-14. PubMed PMID: 25275122; PMCID: 4249131.
14. Navaratnarajah CK, Kumar S, Generous A, Apte-Sengupta S, Mateo M, Cattaneo R. The measles virus hemagglutinin stalk: structures and functions of the central fusion activation and membrane-proximal segments. Journal of virology. 2014;88(11):6158-67. doi: 10.1128/JVI.02846-13. PubMed PMID: 24648460; PMCID: 4093900.
15. Page A, Volchkova VA, Reid SP, Mateo M, Bagnaud-Baule A, Nemirov K, Shurtleff AC, Lawrence P, Reynard O, Ottmann M, Lotteau V, Biswal SS, Thimmulappa RK, Bavari S, Volchkov VE. Marburgvirus hijacks nrf2-dependent pathway by targeting nrf2-negative regulator keap1. Cell reports. 2014;6(6):1026-36. doi: 10.1016/j.celrep.2014.02.027. PubMed PMID: 24630992.
16. Mateo M, Generous A, Sinn PL, Cattaneo R. Connections matter–how viruses use cell-cell adhesion components. Journal of cell science. 2015;128(3):431-9. PubMed PMID: 26046138; PMCID: 4311127.
17. Singh BK, Hornick AL, Krishnamurthy S, Locke AC, Mendoza CA, Mateo M, Miller-Hunt CL, Cattaneo R, Sinn PL. The Nectin-4/Afadin Protein Complex and Intercellular Membrane Pores Contribute to Rapid Spread of Measles Virus in Primary Human Airway Epithelia. Journal of virology. 2015;89(14):7089-96. doi: 10.1128/JVI.00821-15. PubMed PMID: 25926640; PMCID: 4473566.
18. Reynard O, Mateo M. Characterization of the Unconventional Secretion of the Ebola Matrix Protein VP40. Methods in molecular biology. 2016;1459:205-13. doi: 10.1007/978-1-4939-3804-9_14. PubMed PMID: 27665561.
19. Singh BK, Li N, Mark AC, Mateo M, Cattaneo R, Sinn PL. Cell-to-Cell Contact and Nectin-4 Govern Spread of Measles Virus from Primary Human Myeloid Cells to Primary Human Airway Epithelial Cells. Journal of virology. 2016;90(15):6808-17. doi: 10.1128/JVI.00266-16. PubMed PMID: 27194761; PMCID: 4944272.
20. Reynard O, Mateo M. Modeling Ebolavirus Budding with Virus Like Particles. Methods in molecular biology. 2017;1628:109-17. doi: 10.1007/978-1-4939-7116-9_8. PubMed PMID: 28573614.
21. Vernet MA, Reynard S, Fizet A, Schaeffer J, Pannetier D, Guedj J, Rives M, Georges N, Garcia-Bonnet N, Sylla AI, Grovogui P, Kerherve JY, Savio C, Savio-Coste S, de Severac ML, Zloczewski P, Linares S, Harouna S, Abdoul BM, Petitjean F, Samake N, Shepherd S, Kinda M, Koundouno FR, Joxe L, Mateo M, Lecine P, Page A, Tchamdja TM, Schoenhals M, Barbe S, Simon B, Tran-Minh T, Longuet C, L’Heriteau F, Baize S. Clinical, virological, and biological parameters associated with outcomes of Ebola virus infection in Macenta, Guinea. JCI insight. 2017;2(6):e88864. doi: 10.1172/jci.insight.88864. PubMed PMID: 28352651; PMCID: 5358491 exists.
22. Carnec X, Mateo M, Page A, Reynard S, Hortion J, Picard C, Yekwa E, Barrot L, Barron S, Vallve A, Raoul H, Carbonnelle C, Ferron F, Baize S. A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins. Journal of virology. 2018;92(12). doi: 10.1128/JVI.02230-17. PubMed PMID: 29593043; PMCID: 5974477.
23. Schaeffer J, Carnec X, Reynard S, Mateo M, Picard C, Pietrosemoli N, Dillies MA, Baize S. Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells. PLoS pathogens. 2018;14(11):e1007430. doi: 10.1371/journal.ppat.1007430. PubMed PMID: 30419076; PMCID: 6258464.
24. Reynard S, Journeaux A, Gloaguen E, Schaeffer J, Varet H, Pietrosemoli N, Mateo M, Baillet N, Laouenan C, Raoul H, Mullaert J, Baize S. Immune parameters and outcomes during Ebola virus disease. JCI insight. 2019;4(1). doi: 10.1172/jci.insight.125106. PubMed PMID: 30626757.