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Présentation
Projets
Anciennes Équipes
CV
Habilitation à diriger des recherches Université Paris Cité (2023)
Group Leader at Institut Pasteur Paris (since 2020)
Permanent Researcher at Inserm (since 2019)
Research Scientist at Massachusetts Institute of Technology, USA (2016 – 2019)
Postdoctoral fellow at Instituto de Medicina Molecular, Portugal (2010 – 2016)
Doctoral fellow at Institut Pasteur Paris, France (2004 – 2009)
PharmD Universidade do Porto, Portugal (1997 – 2003)
Publications
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2024Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses., Sci Adv 2024 Apr; 10(17): eadm9281.
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2023Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum., iScience 2023 Feb; 26(2): 105940.
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2022Repurposing of Plasmodium falciparum var genes beyond the blood stage., Curr Opin Microbiol 2022 Sep; 70(): 102207.
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2022Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes., Stem Cell Reports 2022 Aug; (): .
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2022Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission., Nat Commun 2022 Jul; 13(1): 4123.
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2022A single-cell liver atlas of Plasmodium vivax infection., Cell Host Microbe 2022 07; 30(7): 1048-1060.e5.
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2022Single-cell views of the Plasmodium life cycle., Trends Parasitol 2022 Jun; (): .
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2021Linking microbiota composition with antimalarial antibody response., Trends Parasitol 2021 10; 37(10): 853-855.
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2020Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes., Proc Natl Acad Sci U S A 2020 01; 117(3): 1678-1688.
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2019Targeting liver stage malaria with metformin., JCI Insight 2019 12; 4(24): .
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