(EN) I was born in Belgium and obtained my Master degree from the University Pierre et Marie Curie, Paris (France). I completed my PhD studies at the Institut Pasteur, Paris (France) on the regulation of the expression of the central genes of the Escherichia coli PEP-dependent phosphotransferase system. During my postdoctoral fellowship, I moved from fundamental to medical microbiology and studied the control of the expression of the pili of the bacterial pathogen Neisseria gonorrhoeae. Since 1995, I am studying the gastric pathogen Helicobacter pylori. I am currently an Associate Professor at the Institut Pasteur and head of the Helicobacter Pathogenesis group since 2008. Since 2014, I am head of the Microbiology department of the Institut Pasteur.
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2018Effect of Helicobacter pylori Infection on GATA-5 and TFF1 Regulation, Comparison Between Pediatric and Adult Patients, Dig. Dis. Sci. 2018 11;63(11):2889-2897.
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2018The Sole DEAD-Box RNA Helicase of the Gastric Pathogen Is Essential for Colonization, MBio 2018 03;9(2).
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2016Characterization in Helicobacter pylori of a Nickel Transporter Essential for Colonization That Was Acquired during Evolution by Gastric Helicobacter Species, PLoS Pathog. 2016 Dec;12(12):e1006018.
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2016RNase J depletion leads to massive changes in mRNA abundance in Helicobacter pylori., RNA Biol. 2016;13(2):243-53. doi: 10.1080/15476286.2015.1132141..
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2015Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization, PLoS Pathog 11(12): e1005312. doi:10.1371/journal. ppat.1005312.
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2015Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones, Open Biol. 2015 Jun;5(6):150015. doi: 10.1098/rsob.150015..
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2014Promiscuous nickel import in human pathogens: structure, thermodynamics, and evolution of extracytoplasmic nickel-binding proteins, Structure 2014 Oct;22(10):1421-32.
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2014Circulating mitochondrial DNA level, a noninvasive biomarker for the early detection of gastric cancer, Cancer Epidemiol. Biomarkers Prev. 2014 Nov;23(11):2430-8.
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2014pH-mediated potentiation of aminoglycosides kills bacterial persisters and eradicates in vivo biofilms, J. Infect. Dis. 2014 Nov;210(9):1357-66.
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2013Common themes and unique proteins for the uptake and trafficking of nickel, a metal essential for the virulence of Helicobacter pylori, Front Cell Infect Microbiol 2013;3:94.
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