Projets Transversaux
Projets
CV
I was born in Belgium and obtained my Master degree from the University Pierre et Marie Curie, Paris (France). I completed my PhD studies at the Institut Pasteur, Paris (France) on the regulation of the expression of the central genes of the Escherichia coli PEP-dependent phosphotransferase system. During my postdoctoral fellowship, I moved from fundamental to medical microbiology and studied the control of the expression of the pili of the bacterial pathogen Neisseria gonorrhoeae. Since 1995, I am studying the gastric pathogen Helicobacter pylori. I am currently an Associate Professor at the Institut Pasteur and head of the Helicobacter Pathogenesis group since 2008. From 2014 to 2019, I was director of the Microbiology department of the Institut Pasteur.
Publications
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2021A novel mode of control of nickel uptake by a multifunctional metallochaperone., PLoS Pathog 2021 Jan; 17(1): e1009193.
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2020A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids., Proc Natl Acad Sci U S A 2020 Nov 23:202016195..
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2020The RNase J-Based RNA Degradosome Is Compartmentalized in the Gastric Pathogen Helicobacter pylori., mBio 2020 Sep; 11(5): .
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2020Orally administrated chitosan microspheres bind Helicobacter pylori and decrease gastric infection in mice., Acta Biomater 2020 09; 114: 206-220.
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2020USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis., Gut 2020 Sep; 69(9): 1582-1591.
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2020Pathogenesis of Helicobacter pylori infection, Helicobacter 2020;00:e12736..
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2020Bacterial RNA Degradosomes: Molecular Machines under Tight Control., Trends Biochem. Sci. 2020 Jan; 45(1): 42-57.
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2019Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Drug-Resistant Clinical Strains and in Infected Mice, J. Med. Chem. 2019 Jul;62(13):6102-6115.
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2018Effect of Helicobacter pylori Infection on GATA-5 and TFF1 Regulation, Comparison Between Pediatric and Adult Patients, Dig. Dis. Sci. 2018 11;63(11):2889-2897.
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2018The Sole DEAD-Box RNA Helicase of the Gastric Pathogen Is Essential for Colonization, MBio 2018 03;9(2).
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