Dorian Obino

(EN)

EDUCATION

• PhD: Institut Curie – INSERM U932 (Paris, France), Immunology – Cell Biology, 2016
• Master/Magistère Européen de Génétique – Université Paris VII (Paris, France), Genetics – Immunology, 2012

RESEARCH EXPERIENCE

• 2017-Now: Institut Pasteur – Pathogenesis of Vascular Infections unit, Dr. Guillaume Duménil, Paris, France – Postdoctral Fellow
• 2012-2016: Institut Curie – INSERM U932, Dr. Ana-Maria Lennon-Duménil, Paris, France – PhD Student
• Ap-Aug 2011: St Jude Children’s Research Hospital, Dr. Peter J. Murray’s lab, Memphis, TN, USA
• June-Aug 2010: Institut Jacques Monod – UMR 7592, Pr. Catherine Alcaïde-Loridan, Paris, France

FELLOWSHIP

• 2018-2020: Pasteur-Roux Postdoctoral Fellowship – Institut Pasteur Paris
• 2015-2016: 4^th year PhD Fellowship – Fondation pour la Recherche Médicale
• 2012-2015: PhD Fellowship – Ecole Doctorale BioSPC, Universités Paris V & VII

AWARDS

• 2016: Académie Nationale de Pharmacie, Prix de Thèse en Sciences Biologiques

COMMUNICATIONS

Posters

• 2015: Actin and microtubule cytoskeleton in cell motility and morphogenesis: an integrated view. J. Monod conference, Roscoff, France – “Actin nucleation at the centrosome controls lymphocyte polarity”
• 2013: SFI (French Society of Immunology) annual meeting, Paris, France – “Galectin-8 promotes efficient antigen processing and presentation by B lymphocytes”
• 2012: Current Trends in Biochemistry, Biophysics and Cell Biology, 39^th Winter School of Faculty of Biochemistry, Biophysics and Biotechnology, Zakopane, Poland – “Tuning B lymphocyte responses through cell polarity and lysosome exocytosis”

 Oral presentations

• 2016: 7^th Edition of YRLS (Young Researchers in Life Science) Conference, Paris, France – “Actin nucleation at the centrosome controls lymphocyte polarity”
• 2013: SFI (French Society of Immunology) annual meeting, Paris, France – “Galectin-8 promotes efficient antigen processing and presentation by B lymphocytes”

TEACHING   

Invited lecturer

• 2015-2016 & 2016-2017: 2^nd year Master’s degree “Biologie Cellulaire, Physiologie et Pathologie, Spécialité Biologie et Développement Cellulaires”, Université Paris Descartes (Paris, France), Course: Membrane dynamics and signaling, Chair: A. Benmerah
• 2012-2013: 3^rd year bachelor’s degree, Magistère Européen de Génétique, Université Paris VII (Paris, France), Course: Cell Biology, Chair: C. Alcaïde-Loridan

Teaching assistant

• Jan 2018 & Jan 2019: Master 2 degree, Molecular Biology of the Cell, Institut Pasteur Course, Practical course: Vasculogenesis in microfluidic devices, Chair: C. Zurzolo
• 2014-2015 & 2015-2016: 1^st year bachelor’s degree, Université Paris VII – Denis Diderot (Paris, France), Practical course: Molecular biology, Chair: V. Joliot

PUBLICATIONS

• 2018

Obino D, Fetler L, Soza A, Malbec O, Saez JJ, Labarca M, Oyanadel C, Del Valle Batalla F, Goles N, Chikina A, Lankar D, Segovia-Miranda F, Garcia C, Léger T, Gonzalez A, Espéli M, Lennon-Duménil AM, Yuseff MI, Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse, Cell Reports, 2018 Dec;25(11):3110-3122.e6.

• 2017

Obino D*, Diaz J*, Sáez JJ, Ibañez-Vega J, Sáez PJ, Alamo M, Lankar D, Yuseff MI, Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes, Mol. Biol. Cell, 2017 Apr;28(7):890-897. * equal contribution

• 2016

Bretou M, Kumari A, Malbec O, Moreau HD, Obino D, Pierobon P, Randrian V, Sáez PJ, Lennon-Duménil AM, Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation, Immunol. Rev., 2016 Jul;272(1):39-51. All authors equally contributed to this work.

Ibáñez L, Abou-Ezzi G, Ciucci T, Amiot V, Belaïd N, Obino D, Mansour A, Rouleau M, Wakkach A, Blin-Wakkach C, Inflammatory Osteoclasts Prime TNFα-Producing CD4(+) T Cells and Express CX3 CR1, J. Bone Miner. Res., 2016 Oct;31(10):1899-1908

Obino D, Farina F, Malbec O, Sáez PJ, Maurin M, Gaillard J, Dingli F, Loew D, Gautreau A, Yuseff MI, Blanchoin L, Théry M, Lennon-Duménil AM, Actin nucleation at the centrosome controls lymphocyte polarity, Nature Communications, 2016 Mar;7:10969.

Vargas P, Maiuri P, Bretou M, Sáez PJ, Pierobon P, Maurin M, Chabaud M, Lankar D, Obino D, Terriac E, Raab M, Thiam HR, Brocker T, Kitchen-Goosen SM, Alberts AS, Sunareni P, Xia S, Li R, Voituriez R, Piel M, Lennon-Duménil AM, Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells, Nat. Cell Biol., 2016 Jan;18(1):43-53.

• 2015

Reversat A#, Yuseff MI#, Lankar D*, Malbec O*, Obino D*, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM, Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse, Mol. Biol. Cell, 2015 Apr;26(7):1273-85. #, * equal contributions

• 2014

Obino D, Lennon-Duménil AM, A critical role for cell polarity in antigen extraction, processing, and presentation by B lymphocytes, Adv. Immunol., 2014;123:51-67.

• 2012

Ghislin S, Obino D, Middendorp S, Boggetto N, Alcaide-Loridan C, Deshayes F, LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro, BMC Cancer, 2012 Oct;12:455.

• 2011

Ghislin S, Obino D, Middendorp S, Boggetto N, Alcaide-Loridan C, Deshayes F, Junctional adhesion molecules are required for melanoma cell lines transendothelial migration in vitro, Pigment Cell Melanoma Res., 2011 Jun;24(3):504-11.