The Structural Biology of Infectious Diseases Unit is a new lab at the Institut Pasteur dedicated to investigate the entry of large DNA viruses into host cells. For this, we combine structural biology, biophysics and virology approaches to characterize protein complexes. We aim to use the resulting information to develop vaccines and therapies.
We are looking for a person with excellent track record and motivation to pursue a career in structural virology. The postdoctoral fellow will be in charge of characterizing protein complexes using cryo-electron microscopy and of setting up functional assays. The project will involve protein and virus purification, neutralization and fusion assays and structural studies by cryo-electron microscopy and x-ray crystallography. The group is hosted in an international and dynamic environment with extensive opportunities to learn new techniques and to establish great collaborations. We have a fully equipped lab for protein and virus production, purification and characterization. The Institut Pasteur is equipped with start-of-the-art microscopes, including two 200 kV Glacios and a 300 kV Titan Krios equipped with a Falcon 4 detector and an energy filter. The synchrotron Soleil is less than 1 hour from the Institut and we have fluid access to the crystallography and biophysics platforms, which are excellently equipped.
· A PhD in structural biology, biochemistry, biophysics or virology.
· Documented experience in one of the following techniques: structural biology (cryo-electron microscopy or x-ray crystallography), virology (manipulation of virus, neutralization assays) or biophysical techniques (viral fusion assays). Experience in handling poxviruses would be a plus.
· Good interpersonal skills
The application should contain
1. A letter of motivation (1 page) with a short description of your research interests.
2. A CV, including a list of relevant skills, experiences and a full publication list.
3. Names and e-mail addresses of 2-3 reference persons, indicating their professional relation to you.
Deadline for applications: 30 January 2023
The starting date is negotiable. Ideally around March 2023, no later than September.
Informal inquiries and application should be sent to Pablo Guardado-Calvo (firstname.lastname@example.org)