Présentation
Department of Developmental and Stem Cell Biology
2017 Seminar Series
Friday 24th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66)
SEMINAR ” Design principles of cell-cell signaling processes “
Invited Speaker ⇒ David Sprinzak
The Center for Nanoscience & Nanotechnology
Department of Biochemistry and Molecular Biology, Tel Aviv Univ. – Israel
Abstract : During development, cells coordinate their cellular states with their neighbors using a variety of intercellular signaling systems. How each signaling system is optimized to perform its unique function during development is one of the main questions in modern developmental biology. We use a combination of synthetic biology, quantitative live cell imaging, and mathematical modeling to elucidate some of the design principles underlying two major juxtacrine signaling pathways: Notch signaling, used to coordinate differentiation between neighboring cells, and Fat-Dachsous signaling, used for coordination of planar cell polarity in epithelial layers. The first part of the talk will focus on how the interplay between Notch signaling and cellular morphology can affect developmental patterning processes. In the second part of the talk, I will describe how localized feedbacks between Fat4-Dachsous1 complexes on the boundary between cells underlie the emergence of planar cell polarity. I will emphasize the link between molecular properties of the signaling molecules and their role in coordinating organization across the whole tissue.
Hosted by François Schweisguth