Présentation
During the JOBIM 2021 conference, we are organizing a virtual mini-symposium on “Integrative structural modeling in the era of big data and artificial intelligence”
The field of structural bioinformatics aims at developing algorithms to tackle the current challenges in 3D structure prediction of biological macromolecules and their functional annotation by exploiting data from genomics and biophysics in combination with systems biology and design, to be applied in biotechnology and therapeutics.
This mini-symposium thus proposes to focus on integrative structural modeling and to address the new challenges, in a redefined landscape owing to the recent developments in experimental biophysics on one hand (the resolution revolution in cryo-EM) and in deep-learning on the other hand (as demonstrated by the extraordinary performances of DeepMind unveiled in December 2020). These rapid changes are a sign of acceleration in structural bioinformatics developments such as structural modeling using cryo-EM or other experimental data providing spatial restraints, progress in machine learning for structural prediction and protein design.
When: July 8th 2021, 15h30 (Paris time)
Where: Online (Registration to JOBIM2021 required but now closed)
Videos recordings: JOBIM 2021 website
Programme: (PDF)
- 15h30-15h40 Introduction:
“Current challenges in 3D modeling of proteins and complexes”
- 15h40-16h10 Riccardo Pellarin (CNRS-Institut Pasteur, Paris)
“Bayesian modeling in integrative structural biology”
- 16h10-16h40 Ezgi Karaca (Izmir Biomedicine and Genome Center, Turquie)
“Dynamic Integrative Modeling of Molecular Machines”
- 16h40-17h00 Pause
- 17h-17h30 Sergei Grudinin (INRIA, Grenoble)
“Entering the post-protein structure prediction era”
- 17h30-18h Slavica Jonic (CNRS-Sorbonne Université, Paris)
“Cryo-EM studies of continuous conformational variability of biomolecules in vitro and in situ based on image analysis, simulation and deep learning”
Organizers: Jessica Andreani, Gwenaëlle André-Leroux, Benjamin Bardiaux, Stéphanie Baud, Isaure Chauvot de Beauchêne, Elodie Laine and Juliette Martin.
Sponsor: GGMM (Groupe de Graphisme et Modélisation Moléculaire) 