First international conference on CK1 PROTEIN KINASES: “FROM CELL SIGNALING TO THERAPEUTIC TARGETS IN HUMAN DISEASE”

We are pleased to announce, The first international conference on CK1 PROTEIN KINASES: “FROM CELL SIGNALING TO THERAPEUTIC TARGETS IN HUMAN DISEASE”. The event will take place from February 3rd to February 6, 2025, at the Institut Pasteur in Paris, France.

Casein kinase 1 (CK1) is a family of serine/threonine protein kinases that play essential regulatory functions in numerous cellular processes. Defects in CK1 regulation, localization, or mutations within the CK1 coding sequence are associated with critical human diseases such as cancer, neurodegenerative diseases, and sleeping disorders. Therefore, members of the CK1 family have become interesting new drug target molecules, with each paralog having different therapeutic effects. Additionally, there are increasing evidence that intracellular pathogens link CK1 to infectious diseases by manipulating CK1 signalling pathways within host cells.

The conference program aims to encourage the exchange between various scientific communities, promote new lines of research on CK1, and enhance communication, collaboration, and career development for scientists, especially young researchers, from various disciplines. The conference sessions will present and discuss research results from the following areas:

• CK1 in development and regeneration
• Exploring CK1 function in model organisms
• CK1 structure and mechanisms of regulation
• CK1 and circadian clocks
• CK1 in human diseases, part I cancer
• CK1 in human diseases, part II neurodegenerative diseases
• CK1 in human diseases, part III infectious diseases
• Spatial and temporal aspects of signaling
• Targeting CK1 for therapy, part I and II

A round table will also be organised to discuss ways to collaborate on CK1 between different fields.

Prominent scientists in the CK1 community have confirmed their participation as keynote speakers, including:

Special keynote lecture: Lorenzo Pinna (University of Padova, Italy)

Opening keynote speaker: David Virshup (Duke-NUS, Singapore), Closing keynote speaker: Volker Dötsch (Goethe university, Germany)

Session keynote speakers: Nagi G Ayad (Georgetown University, USA), Kathy Gould (Vanderbilt university, USA), Nicolas Thomä (The Friedrich Miescher Institute for Biomedical Research, Switzerland), Carrie Partch (University of California Santa Cruz, USA), Stephanie Federico (University of Trieste, Italy), Yinon Ben-Neriah (The Hebrew university of Jerusalem, Israel), David Strutt (University of Sheffield, United Kingdom), Stefan Knapp (SGC Frankfurt, Germany), Nicolas Robbins (University of Toronto, Canada).

Networking events such as poster sessions and industry exhibitions will also encourage discussions within the CK1 community.

Who should attend?

This event is for all scientists who wish to deepen their knowledge of CK1, as well as those interested in drug target identification, drug discovery for various human diseases.

The organizing committee:

• Najma Rachidi, Institut Pasteur, France
• Uwe Knippschild, University of Ulm, Germany
• Gopal Sapkota, University of Dundee, UK
• Carrie Partch, University of California Santa Cruz, USA
• Vítězslav Bryja, Masaryk University, Czech Republic
• Pascal Marchand, Nantes University, France
• Kathy Gould, Vanderbilt University, USA

The draft programme:

DAY 1

15:00-17:00: Arrival and registration
17:00-17:10: Introduction Najma Rachidi & Uwe Knippschild

17:10-18:00: Professor Lorenzo Pinna and Casein Kinases (Professor Pinna and Dr Venerando)

18:10-19:00: Opening Keynote lecture: David Virshup (Duke-NUS, Singapore, https://www.duke-nus.edu.sg/cscb/the-team/primary-faculty/Details/detail/david-marc-virshup)

Chair: Najma Rachidi & Uwe Knippschild

19:00-20:15: Session 1 – CK1 in development and regeneration
Chair: TBA
19:00-19:30 Keynote lecture: Nagi G Ayad (Georgetown university, USA, https://sites.google.com/georgetown.edu/ayadlab/home)

19:30-19:45 Speaker: TBA
19:45-20:00 Speaker: TBA
20:00-20:15 Speaker: TBA

20:15-21:30 Welcome drinks and finger food

DAY 2

09:00-10:55: Session 2 – Exploring CK1 function in model organisms
Chair: TBA
09:00-09:30 Keynote lecture: Kathy Gould (Vanderbilt University, USA, https://lab.vanderbilt.edu/gould-lab/)

09:30-09:45 Speaker: TBA

09:45-10:00 Speaker: TBA

10:00-10:15 Speaker: TBA
10:15-10:30 Speaker: TBA

10:30-11:00 Coffee break

11:00-12:45: Session 3: – CK1 molecular structure and regulation
Chair: TBA
11:00-11:30 Keynote lecture: Nicolas Thomä (The Friedrich Miescher Institute for Biomedical Research, Switzerland, https://www.fmi.ch/research-groups/groupleader.html?group=118)

11:30-11:45 Speaker: Gopal Sapkota (University of Dundee, UK, https://www.ppu.mrc.ac.uk/research/principal-investigator/gopal-sapkota)
11:45-12:00 Speaker: TBA
12:00-12:15 Speaker: TBA

12:15-12:25 5 Turbo talks selected from abstracts (I, 2 min each no question)

12:25-15:30: Lunch on campus. Session on How to finance CK1 networks on the European and world levels

15:30-16:40: Session 4 – CK1 and circadian clocks
Chair: TBA
15:30-16:00 Keynote lecture: Carrie Partch (University of California Santa Cruz, USA, https://www.partchlab.com/)

16:00-16:15 Speaker: TBA
16:15-16:30 Speaker: TBA
16:30-16:40 Speaker: TBA

16:40-17h00 Coffee break

17:00-18:30: Session 5 – Novel roles for CK1 (open to the newest/most exciting data)

Chair: TBA
17:00-17:15 speaker: TBA

17:15-17:30 speaker: TBA
17:30-17:45 speaker: TBA

17:45-17:55 5 Turbo talks selected from abstracts (II)

18:00-20:00 Poster session A and drinks

DAY 3

09:00-10:30: Session 6 – CK1 in human diseases, part I cancer
Chair: TBA
09:00-09:30 Keynote lecture: Cancer: Yinon Ben-Neriah (The Hebrew university of Jerusalem, Israel, https://medicine.ekmd.huji.ac.il/en/research/yinonb/Pages/default.aspx).

09:30-09:45 speaker: Uwe Knippschild (University of Ulm, Germany, https://www.uniklinik-ulm.de/allgemein-und-viszeralchirurgie/forschung-studien/grundlagenforschung/forschungsleitung-prof-dr-knippschild.html)
09:45-10:00 speaker: TBA
10:00-10:15 speaker: TBA
10:15-10:30 speaker: TBA

10:30-11:00 Coffee break

11:00-12:15: Session 7 – CK1 in human diseases, part II neurodegenerative diseases
Chair: TBA
11:00-11:30 Keynote speaker: Alzheimer disease: Stephanie Federico (University of Trieste, Italy, https://dscf.units.it/en/node/1158).

11:30-11:45 speaker: TBA

11:45-12:00 speaker: TBA
12:00-12:15 speaker: TBA

12:15-13:00: Session 8 – CK1 in human diseases, part III infectious diseases

Chair: TBA
12:15-12:30 speaker: Leishmaniasis, Najma Rachidi (Institut Pasteur, France, https://research.pasteur.fr/en/team/signalling-and-host-parasite-interactions/)
12:30-12:45 speaker: TBA

12:45-13:00 speaker: TBA

13:00-15:30: Lunch on campus. Session on fundraising opportunities to create CK1 networks on the European and world levels

15:30-17:00: Session 9 – Spatial and temporal signalling
Chair: TBA
15:30-16:00 Keynote lecture: David Strutt (University of Sheffield, UK, https://www.sheffield.ac.uk/biosciences/people/academic-staff/david-strutt)
16:00-16:15 speaker: TBA
16:15-16:30 speaker: TBA
16:30-16:45 speaker: TBA
16:45-17:00 speaker: TBA

17:00-17:10 5 Turbo talks selected from abstracts (III)

17:10-18:10 Round table, collaborative research on CK1

18:10-20:10 Poster session B and drinks

20:30-23:00 Gala dinner

DAY 4

09:00-10:30: Session 10 – Targeting CK1 for therapy I
Chair: TBA
09:00-09:30 Keynote lecture: Stefan Knapp (SGC Frankfurt, https://www.thesgc.org/groupprofile/9492)
09:30-09:45 speaker: Vítězslav Bryja (Masaryk University, Czech Republic, https://www.muni.cz/en/people/11088-vitezslav-bryja)
09:45-10:00 speaker: TBA
10:00-10:15 speaker: TBA
10:15-10:30 speaker: TBA

10:30-11:00 Coffee break

11:00-12:45: Session 11 – Targeting CK1 for therapy II
Chair: TBA
11:00-11:30 Keynote lecture: Nicole Robbins (University of Toronto, Canada, http://individual.utoronto.ca/cowen/)

11:30-11:45 speaker: Pascal Marchand (University of Nantes, France, https://iicimed.univ-nantes.fr/en);
11:45-12:00 speaker: TBA

12:00-13:00: Closing Keynote lecture: Volker Dötsch (Goethe university, Germany, https://doetsch-lab.de/research/)

13:00-13:15: Closing remarks: Najma Rachidi & Uwe Knippschild

Important dates:

• Registration opening: end of January, 2024
  • https://www.ck1.conferences-pasteur.org
  • ck1@conferences-pasteur.org
• Abstract submission deadline: November 1, 2024
• Early registration deadline : August 1, 2024
• Registration deadline : January 20, 2025
• Last day for registration cancellation with full refund, minus a 50€ processing fee: September 1, 2024 (early registration).

We look forward to welcoming you to this exciting event. Please visit our website for more information on registration and abstract submission.