Timeline

Laurence Dugue

Technician

03 Jan 2020

publication

An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases

20 Jun 2019

publication

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4

02 Feb 2019

publication

First-in-class allosteric inhibitors of bacterial IMPDHs

02 Jan 2019

publication

2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates

09 Mar 2018

project

Protein synthesis machinery of Trypanosomatid as a therapeutic target

09 Jan 2018

team

Epigenetic Chemical Biology

12 Sep 2017

publication

An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

11 Mar 2016

publication

Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation

03 Sep 2015

project

Inhibitors of Pseudomonas aeruginosa IMPDH

20 Aug 2015

project

Inhibitors of TMPK from Mycobacterium tuberculosis

28 Jul 2015

project

Inhibitors of bacterial NAD kinases

12 Nov 2014

publication

A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction

06 Jun 2012

publication

Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound.

01 Jan 2008

publication

Expanding substrate specificity of nucleoside 2′-deoxyribosyltransferase

01 May 2002

publication

Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide

01 Jan 2002

publication

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Timeline

An expedient synthesis of flexible nucleosides through enzymatic glycosylation of proximal and distal fleximer bases

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4

First-in-class allosteric inhibitors of bacterial IMPDHs

2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates

Protein synthesis machinery of Trypanosomatid as a therapeutic target

Epigenetic Chemical Biology

An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation

Inhibitors of Pseudomonas aeruginosa IMPDH

Inhibitors of TMPK from Mycobacterium tuberculosis

Inhibitors of bacterial NAD kinases

A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction

Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound.

Expanding substrate specificity of nucleoside 2′-deoxyribosyltransferase

Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications