Timeline

Laurence Dugue

Technician

20 Jun 2019

publication

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4

02 Feb 2019

publication

First-in-class allosteric inhibitors of bacterial IMPDHs

02 Jan 2019

team

Organic Chemistry

02 Jan 2019

publication

2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates

09 Mar 2018

project

Protein synthesis machinery of Trypanosomatid as a therapeutic target

12 Sep 2017

publication

An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

18 Nov 2016

team

Group : Sylvie Pochet

11 Mar 2016

publication

Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation

03 Sep 2015

project

Inhibitors of Pseudomonas aeruginosa IMPDH

20 Aug 2015

project

Inhibitors of TMPK from Mycobacterium tuberculosis

28 Jul 2015

project

Inhibitors of bacterial NAD kinases

11 May 2015

team

Chemistry and Biocatalysis

12 Nov 2014

publication

A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction

17 May 2012

publication

Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound

01 Jan 2008

publication

Expanding substrate specificity of nucleoside 2′-deoxyribosyltransferase

01 May 2002

publication

Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide

01 Jan 2002

publication

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Timeline

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4

First-in-class allosteric inhibitors of bacterial IMPDHs

Organic Chemistry

2′-Deoxyribonucleoside 5′-triphosphates bearing 4-phenyl and 4-pyrimidinyl imidazoles as DNA polymerase substrates

Protein synthesis machinery of Trypanosomatid as a therapeutic target

An expedient synthesis of flexible nucleosides via a regiocontrolled enzymatic glycosylation of functionalized imidazoles

Group : Sylvie Pochet

Expedient and generic synthesis of imidazole nucleosides by enzymatic transglycosylation

Inhibitors of Pseudomonas aeruginosa IMPDH

Inhibitors of TMPK from Mycobacterium tuberculosis

Inhibitors of bacterial NAD kinases

Chemistry and Biocatalysis

A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki-Miyaura cross-coupling reaction

Screening and in situ synthesis using crystals of a NAD kinase lead to a potent antistaphylococcal compound

Expanding substrate specificity of nucleoside 2′-deoxyribosyltransferase

Synthesis and recognition by DNA polymerases of a reactive nucleoside, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-imidazole-4-hydrazide

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications