Timeline

Christel Brou
Group Leader
17 Nov 2018
project

Role of TNTs in tumor networking, heterogeneity, and resistance to therapy.

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11 May 2015
team

Membrane Traffic and Pathogenesis

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01 Apr 2014
publication

Α-arrestins – new players in Notch and GPCR signaling pathways in mammals

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01 Jan 2014
publication

Tracking trafficking of Notch and its ligands in mammalian cells

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25 Jul 2013
publication

Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals

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09 Jul 2012
publication

The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation

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23 Nov 2010
publication

The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation

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25 Sep 2008
publication

Intracellular trafficking of Notch receptors and ligands

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16 Jul 2008
publication

AIP4/Itch regulates Notch receptor degradation in the absence of ligand

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06 Oct 2006
publication

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

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15 Jun 2005
publication

Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein

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14 Oct 2004
publication

The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration

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01 Jul 2004
publication

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

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06 Jun 2003
publication

The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

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