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© Research
Publication : Experimental cell research

Intracellular trafficking of Notch receptors and ligands

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Experimental cell research - 25 Sep 2008

Brou C

Link to Pubmed [PMID] – 18845146

Exp. Cell Res. 2009 May;315(9):1549-55

The Notch pathway represents a highly conserved signaling network, which regulates the formation and maintenance of various organ systems along development and during adulthood. Direct cell-cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway. Notch signaling requires endocytosis in both signal emitting and receiving cells. Recent findings on the roles of a number of modulators show that they act either on the maintenance of an active receptor at the membrane, or on the production of active ligand, or on signal transduction after activation.

http://www.ncbi.nlm.nih.gov/pubmed/18845146