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About

MD, PhD, Head of Laboratory

Project Summary: Bionomics, Receptivity to Plasmodium falciparum and Susceptibility to insecticides of Anopheles sergentii in the Maghreb.
summary::In the Maghreb, Plasmodium vivax and P. falciparum are the main species involved to malaria. In Tunisia and Morocco, the disease was eliminated in 1979 and in 2008 respectively and only imported cases are reported nowadays. In Algeria, malaria transmission is still present mainly in the south of the country where authochtonous cases are regularly registered.An. labranchiae in the northern parts of the Maghreb, and An. sergentii in the southern parts of this region, are considered as the main vectors of the disease. While the first was largely studied, the second species suffers on lack of data.The Maghreb remains vulnerable because of the intensive circulation of gametocytes carriers, the lack of protective immunity of resident population and the presence of potential vectors in formerly malarious areas. This risk of re emergence of malaria in this region may change with climatic and environmental modi?cations, as well as with increasing of imported malaria from sub-Saharan Africa.An. sergentii has been considered to have two geographical forms An. Sergentii sergentii Theobald and An. Sergentii macmahoni Evans , but some confusion persist on their taxonomic status.
The bionomics of An. sergentii, its ability to transmit tropical strains of P. falciparum and its status regarding susceptibility to insecticides are poorly known. Those are the specific features that need to be investigated in order to enhance epidemiological surveillance considering that the present situation is subject to change due to social and political problems prevailing in sub-Saharan countries and in North Africa. The specific objectives are:
1. To study the systematic status of An. sergentii in the Maghreb
2. To study bio-ecology and vectorial capacity of An. sergentii
3. To evaluate the status of insecticide resistance of An. sergentii
4 . To measure the infectability of An. sergentii with Afro-tropical strains of P. falciparum.
5. To map the malaria risk by confronting An. sergentii entomological data and records of past and present data on malaria cases in Algeria, Tunisia and Morocco.
In the selected field study sites in Algeria (Biskra, Ghardaia ), Tunisia (Tozeur, Tataouine) and Morocco (Marrakech,Taounate), mosquito, larvae and adults, will be regularly sampled using standardized methods and common protocols to ensure a good evaluation and interpretation of the results given by partners. This study will provide baselines information on An. sergentii bionomics and its role in the transmission of the malaria in the North Africa. We also expect to have information about insecticide susceptibility of this species to propose alternative plans to control malaria in the Maghreb region

Events

View Past Events

Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone

Building: 67 - Metchnikoff – Room: Jules Bordet – Address: Institut Pasteur, 25-28 Rue du Docteur Roux, Paris, France
2018-09-26 14:00:00 2018-09-26 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, 25-28 Rue du Docteur Roux, Paris, France

Patients shake research tree up – Peter Kapitein, Hugues Fischer

Building: François Jacob – Room: amphithéâtre François Jacob – Address: Institut Pasteur
2018-09-26 17:00:00 2018-09-26 18:00:00 Europe/Paris Patients shake research tree up   “We want to be at the table and not on the menu” Peter Kapitein For a very long time, patients were the end users of health research without being involved in its process. […] Institut Pasteur

Department of Microbiology : “How microbes keep their CRISPR memories functional and up to date”, by Prof Stan J.J. BROUNS – Stan J.J. BROUNS

Building: Centre François Jacob – Room: Auditorium Centre François Jacob – Address: 28 Rue du Docteur Roux, Paris, France
2018-09-28 11:30:00 2018-09-28 12:30:00 Europe/Paris Department of Microbiology : “How microbes keep their CRISPR memories functional and up to date”, by Prof Stan J.J. BROUNS The CRISPR immune system protects bacteria and archaea from invading viruses and plasmids. Immunity depends on protein diverse protein complexes that use small RNA molecules to find matching viral or plasmid DNA. I will […] 28 Rue du Docteur Roux, Paris, France

Annual meeting 2018 of GdR CellTiss and workshop in honor of Françoise Brochard-Wyart

Address: Nomade Lodge, Ferme de la Boulaye, La Chapelle-Gauthier, France
2018-10-01 14:00:00 2018-10-03 14:00:00 Europe/Paris Annual meeting 2018 of GdR CellTiss and workshop in honor of Françoise Brochard-Wyart GDR CellTiss Annual Days 2018 & Workshop “Be Simple”: From soft matter to cell biophysics An international workshop entitled “Be Simple” will be organized to celebrate the distinguished scientific career of Françoise Brochard-Wyart and […] Nomade Lodge, Ferme de la Boulaye, La Chapelle-Gauthier, France

Binless: bayesian normalization of Hi-C data provides significant interaction and difference detection independently of resolution – Yannick Spill

Building: Sergent, Institut Pasteur – Room: RDC 06 – Address: 25 Rue du Dr Roux, Paris, France
2018-10-04 11:00:00 2018-10-04 12:30:00 Europe/Paris Binless: bayesian normalization of Hi-C data provides significant interaction and difference detection independently of resolution 3C-like experiments, such as 4C or Hi-C, have been fundamental in understanding genome organization. Thanks to these technologies, it is now known, for example, that Topologically Associating Domains (TADs) and chromatin loops are implicated […] 25 Rue du Dr Roux, Paris, France

C3BI Seminars – Signatures of ecological processes in microbial community time series – Karoline Faust

Building: BIME – Room: Francois Jacob Auditorium – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2018-10-04 14:00:00 2018-10-04 15:00:00 Europe/Paris C3BI Seminars – Signatures of ecological processes in microbial community time series Nowadays, a number of densely sampled microbial community time series is available, where the abundance of community members is tracked over several months through sequencing. These data allow exploring community dynamics by investigating signatures […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Soutenance de Thèse : Signalisation cellulaire et peptides antimicrobiens : Rôle de la voie EGFR dans la régulation de la ß-défensine 1 humaine – Clément Bonamy

Building: François Jacob – Room: Auditorium – Address: 25 Rue du Dr Roux, 75015 Paris, France
2018-10-05 14:00:00 2018-10-05 17:00:00 Europe/Paris Soutenance de Thèse : Signalisation cellulaire et peptides antimicrobiens : Rôle de la voie EGFR dans la régulation de la ß-défensine 1 humaine Soutenance de Thèse de Doctorat  Infectiologie – Microbiologie   Université Sorbonne Paris Cité, Préparée à l’Université Paris Diderot, Ecole doctorale BioSPC ED562   25 Rue du Dr Roux, 75015 Paris, France

8th ASM Conference on Biofilms

Address: Omni Shoreham Hotel, 2500 Calvert St NW, Washington D.C., DC, United States
2018-10-07 00:00:00 2018-10-11 23:00:00 Europe/Paris 8th ASM Conference on Biofilms The 8th ASM Conference on Biofilms will be held October 7 – 11, 2018, in Washington, DC. It will provide a platform to discuss the latest research, covering topics that range from diagnosis and […] Omni Shoreham Hotel, 2500 Calvert St NW, Washington D.C., DC, United States

Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology” – Galit Alter

Building: Lwoff - 22 – Room: Room 14, Ground floor – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2018-10-10 17:00:00 2018-10-10 18:00:00 Europe/Paris Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology” Pr. Galit Alter, from the Ragon Institute, Massachusetts General Hospital (Cambridge, USA), will present her  recent work on defining the correlates of protection in SIV and HIV vaccination studies. She will discuss how advances […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Journée de présentation des postes d’accueil

Building: Duclaux – Room: Amphithéâtre Duclaux – Address: Institut Pasteur, Paris, France
2018-10-11 14:00:00 2018-10-11 19:00:00 Europe/Paris Journée de présentation des postes d’accueil Jeudi 11 octobre 2018, l’AP-HP et ses 12 partenaires organisent la seconde édition des Rencontres Postes d’accueil. Cet événement est l’occasion de mettre en valeur le dispositif des Postes d’accueil, permettant à des personnels […] Institut Pasteur, Paris, France

Soutenance de Thèse : Dual role of three natural molecules in regulating the expression of β-defensin-3 and pro-inflammatory mediators. – Erica Telford

Building: Salle Jules Bordet – Room: Salle Jules Bordet – Address: 25 Rue du Dr Roux, 75015 Paris, France
2018-10-11 14:00:00 2018-10-11 17:00:00 Europe/Paris Soutenance de Thèse : Dual role of three natural molecules in regulating the expression of β-defensin-3 and pro-inflammatory mediators. Thèse de Doctorat Infectiologie – Microbiologie Université Sorbonne Paris Cité  Préparée à l’Université Paris Diderot Ecole doctorale Bio Sorbonne Paris Cité – ED562 25 Rue du Dr Roux, 75015 Paris, France

Department of Microbiology and Department of Structural Biology & Chemistry : “Structure and function of the type 6 secretion system, a bacterial weapon of mass destruction”, by Chiara RAPISARDA

Building: Centre François Jacob – Room: Auditorium Centre François Jacob – Address: 28 Rue du Docteur Roux, Paris, France
2018-10-12 11:30:00 2018-10-12 12:30:00 Europe/Paris Department of Microbiology and Department of Structural Biology & Chemistry : “Structure and function of the type 6 secretion system, a bacterial weapon of mass destruction”, by Chiara RAPISARDA The Type VI Secretion System is a well-characterized complex that bacteria use to either defend themselves or to attack other cells, either prokaryotic or eukaryotic. It is composed of a membrane-anchoring complex and a […] 28 Rue du Docteur Roux, Paris, France

Paris Biological Physics Community Day / October 15th

Address: Collège des Irlandais - Salle Michel Guillaume - 5 rue des Irlandais 75005 Paris
2018-10-15 09:00:00 2018-10-15 18:00:00 Europe/Paris Paris Biological Physics Community Day / October 15th Interested in Biological Physics? Want to hear interesting talks, and to connect and discuss with like-minded researchers on this fascinating, multi-disciplinary subject? Then please join us for this year’s Paris Biological Physics Community Day […] Collège des Irlandais - Salle Michel Guillaume - 5 rue des Irlandais 75005 Paris

International Conference on Physics and Biological Systems, Oct 22-24 2018, Gif-sur-Yvette – Arezki Boudaoud, Giovanni Cappello, Guillaume Charras, Sarah Cuylen-Häring, Ulrike Endesfelder, Benjamin Engel, Valérie Gabelica, Gary Karpen, Laëtitia Kurzawa, Amélie Leforestier, Laura Marcu, Boris Martinac, Davide Marenduzzo, Elliot Meyerowitz, Thomas Perkins, Rob Phillips, Rudi Podgornik, Yitzhak Tor, Shelly Tzlil, TomasoZambelli

Address: CNRS Campus 1 Avenue de la Terrasse, 91190 Gif-sur-Yvette
2018-10-22 08:30:00 2018-10-24 18:15:00 Europe/Paris International Conference on Physics and Biological Systems, Oct 22-24 2018, Gif-sur-Yvette The 4th International Conference on Physics and Biological Systems PhysBio 2018 will be held on Oct 22-24 2018 in Gif-sur-Yvette. It aims to bring together a broad range of physical and life scientists working at the […] CNRS Campus 1 Avenue de la Terrasse, 91190 Gif-sur-Yvette

Past events

View Upcoming Events

“Decoding toxin-parasite interactions in Trypanosomatids”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2015-10-08 14:00:00 2015-10-08 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Parasitology in the 21st century”

Building: Duclaux (01) – Room: Amphithéâtre Duclaux – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2015-11-23 14:00:00 2015-11-24 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Research on Malaria transmission stages”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2015-12-16 14:00:00 2015-12-16 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Breadth of the humoral response and antigenic targets associated with protection following experimental Plasmodium falciparum sporozoite inoculation in humans”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2015-12-17 14:00:00 2015-12-17 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Trans-splicing and RNA modification regulate the life and death of Trypanosoma brucei”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-01-07 14:00:00 2016-01-07 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“High throughput approaches to understanding Plasmodium erythrocyte invasion”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-01-21 14:00:00 2016-01-21 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Protection against malaria is induced by blood stage-arresting Histamine Releasing Factor (HRF)-deficient Plasmodium parasites”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-01-28 14:00:00 2016-01-28 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Avian malaria and the evolutionary ecology of host-parasite interactions”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-02-04 14:00:00 2016-02-04 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

Scientific Day on Genome Editing Technology : CRISPR-Cas9 Seminar – James Goldmeyer, Janine Scholefield

Building: Monod (66) – Room: Amphithéâtre – Address: Institut Pasteur, Paris, France
2016-02-11 14:00:00 2016-02-11 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Paris, France

“The impact of hotspot targeted interventions on malaria transmission: an example of different scientific disciplines investigating public health solutions”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-02-18 14:00:00 2016-02-18 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Study of human hepatotropic pathogens in mice with humanized live”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-02-24 14:00:00 2016-02-24 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Establishing a road map of the developmental program leading to infectivity in African trypanosomes”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-03-17 14:00:00 2016-03-17 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Coat replacement dynamics in the African trypanosome”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-03-24 14:00:00 2016-03-24 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“P.falciparum resistance to artemisinins: who cares?”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-03-31 14:00:00 2016-03-31 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

“Insights into the B cell and Tfh cell biology underlying the inefficient acquisition of humoral immunity to malaria”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-04-07 14:00:00 2016-04-07 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Rue du Docteur Roux, Paris, France

Advancing scientific innovations with ECHO Acoustic Liquid Handling – Rosemary Burke, Stephan Lorenz, Richard Ellson

Building: Lwoff – Room: RDC-14/15 – Address: Institut Pasteur, Paris, France
2016-04-15 14:00:00 2016-04-15 16:45:00 Europe/Paris Thesis Defence by Jean-David Morel: Mechanism underpinning the immunosuppressive effects of the mycobacterial macrolide mycolactone Institut Pasteur, Paris, France

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