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© Research
Publication : Developmental and comparative immunology

Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental and comparative immunology - 21 Dec 2015

Aleksejeva E, Houel A, Briolat V, Levraud JP, Langevin C, Boudinot P

Link to Pubmed [PMID] – 26719025

Dev. Comp. Immunol. 2016 Apr;57:48-56

The BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms.