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© Research
Publication : The Journal of infectious diseases

Whole-transcriptome analysis of Plasmodium falciparum field isolates: identification of new pathogenicity factors

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 25 Oct 2007

Siau A, Toure FS, Ouwe-Missi-Oukem-Boyer O, Ciceron L, Mahmoudi N, Vaquero C, Froissard P, Bisvigou U, Bisser S, Coppee JY, Bischoff E, David PH, Mazier D

Link to Pubmed [PMID] – 18008243

J. Infect. Dis. 2007 Dec;196(11):1603-12

Severe malaria and one of its most important pathogenic processes, cerebral malaria, involves the sequestration of parasitized red blood cells (pRBCs) in brain postcapillary venules. Although the pathogenic mechanisms underlying malaria remain poorly characterized, it has been established that adhesion of pRBCs to endothelial cells (ECs) can result in cell apoptosis, which in turn may lead to disruption of the blood-brain barrier. The nature of the parasite molecules involved in the pathogenesis of severe malaria remains elusive.

http://www.ncbi.nlm.nih.gov/pubmed/18008243