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© Research
Publication : Experimental cell research

WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics.

Team: Biological Image Analysis
Member: Jean-Christophe Olivo-Marin
Member: Philippe Sansonetti
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Experimental cell research - 01 Apr 2009

Viklund IM, Aspenström P, Meas-Yedid V, Zhang B, Kopec J, Agren D, Schneider G, D'Amato M, Olivo-Marin JC, Sansonetti P, Van Nhieu GT, Pettersson S,

Link to Pubmed [PMID] – 19121306

Link to DOI – 10.1016/j.yexcr.2008.12.004

Exp Cell Res 2009 Apr; 315(6): 1040-52

We have previously identified a new gene with sequence homology to the WASP-family of actin regulators denoted WAFL (WASP and FKBP-like). Here we report a possible biological function for WAFL, by demonstrating an association to early endosomes via its central coiled-coil domain. Further we show by functional and structural studies that WAFL is associated with both microtubules and the actin filament system, the two means of transport of early endosomes. In addition, WAFL interacts with WASP-interacting protein (WIP) and actin, thus linking WAFL to actin dynamics. The use of RNAi depletion of WAFL shows that WAFL-deficient cells display delayed transport of endosomal cargo. Our findings are compatible with a model whereby WAFL is involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.