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© Research
Publication : Infection and immunity

Virulent Brucella abortus prevents lysosome fusion and is distributed within autophagosome-like compartments

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 May 1998

Pizarro-Cerdá J, Moreno E, Sanguedolce V, Mege JL, Gorvel JP

Link to Pubmed [PMID] – 9573138

Infect. Immun. 1998 May;66(5):2387-92

Virulent and attenuated Brucella abortus strains attach to and penetrate nonprofessional phagocytic HeLa cells. Compared to pathogenic Brucella, the attenuated strain 19 hardly replicates within cells. The majority of the strain 19 bacteria colocalized with the lysosome marker cathepsin D, suggesting that Brucella-containing phagosomes had fused with lysosomes, in which they may have degraded. The virulent bacteria prevented lysosome-phagosome fusion and were found distributed in the perinuclear region within compartments resembling autophagosomes.

http://www.ncbi.nlm.nih.gov/pubmed/9573138