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© Therese Couderc, Marc Lecuit
Publication : Biologicals : journal of the International Association of Biological Standardization

Viral diversity in swine intestinal mucus used for the manufacture of heparin as analyzed by high-throughput sequencing

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biologicals : journal of the International Association of Biological Standardization - 15 Nov 2014

Dumarest M, Muth E, Cheval J, Gratigny M, Hébert C, Gagnieur L, Eloit M

Link to Pubmed [PMID] – 25466699

Biologicals 2015 Jan;43(1):31-6

Heparin is one of the main pharmaceutical products manufactured from raw animal material. In order to describe the viral burden associated with this raw material, we performed high-throughput sequencing (HTS) on mucus samples destined for heparin manufacturing, which were collected from European pigs. We identified Circoviridae and Parvoviridae members as the most prevalent contaminating viruses, together with viruses from the Picornaviridae, Astroviridae, Reoviridae, Caliciviridae, Adenoviridae, Birnaviridae, and Anelloviridae families. Putative new viral species were also identified. The load of several known or novel small non-enveloped viruses, which are particularly difficult to inactivate or eliminate during heparin processing, was quantified by qPCR. Analysis of the combined HTS and specific qPCR results will influence the refining and validation of inactivation procedures, as well as aiding in risk analysis of viral heparin contamination.

http://www.ncbi.nlm.nih.gov/pubmed/25466699