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© Melanie Blokesch, EPFL
Flagellated Vibrio cholerae
Publication : Antimicrobial agents and chemotherapy

Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.

Team: Bacterial Genome Plasticity
Team: Bacterial responses to antimicrobial stress
Member: Didier Mazel
Member: Zeynep Baharoglu
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 01 May 2011

Baharoglu Z, Mazel D,

Link to Pubmed [PMID] – 21300836

Link to DOI – 10.1128/AAC.01549-10

Antimicrob Agents Chemother 2011 May; 55(5): 2438-41

Antibiotic resistance development has been linked to the bacterial SOS stress response. In Escherichia coli, fluoroquinolones are known to induce SOS, whereas other antibiotics, such as aminoglycosides, tetracycline, and chloramphenicol, do not. Here we address whether various antibiotics induce SOS in Vibrio cholerae. Reporter green fluorescent protein (GFP) fusions were used to measure the response of SOS-regulated promoters to subinhibitory concentrations of antibiotics. We show that unlike the situation with E. coli, all these antibiotics induce SOS in V. cholerae.