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© Emmanuel Lemichez
Microscopy image showing the formation of large tunnels in a blood vessel endothelial cell induced by a group of bacterial toxins
Publication : Toxins

Variability of Botulinum Toxins: Challenges and Opportunities for the Future

Team: Bacterial Toxins
Member: Emmanuel Lemichez
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Toxins - 13 Sep 2018

Rasetti-Escargueil C, Lemichez E, Popoff MR

Link to Pubmed [PMID] – 30217070

Toxins (Basel) 2018 Sep;10(9)

Botulinum neurotoxins (BoNTs) are the most potent known toxins, and are therefore classified as extremely harmful biological weapons. However, BoNTs are therapeutic drugs that are widely used and have an increasing number of applications. BoNTs show a high diversity and are divided into multiple types and subtypes. Better understanding of the activity at the molecular and clinical levels of the natural BoNT variants as well as the development of BoNT-based chimeric molecules opens the door to novel medical applications such as silencing the sensory neurons at targeted areas and dermal restoration. This short review is focused on BoNTs’ variability and the opportunities or challenges posed for future clinical applications.