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© Clifton E. Barry III, Ph.D., NIAID, NIH.
Colorized scanning electron micrograph of Mycobacterium tuberculosis
Publication : Planet-Vie

Un nouveau concept pour améliorer le vaccin antituberculeux

Team: Integrated Mycobacterial Pathogenomics
Member: Laleh Majlessi
Member: Roland Brosch
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Planet-Vie - 28 Aug 2017

Majlessi, L & Brosch R

Planet-Vie (Ressources en sciences de la vie pour les enseignants), Lundi 28 août 2017

Un nouveau concept pour améliorer le vaccin antituberculeux, Planet-Vie,

Abstract

La tuberculose est une maladie humaine causée par la bactérie Mycobacterium tuberculosis et qui est responsable chaque année de plus d’un million et demi de décès dans le monde. Le vaccin traditionnellement utilisé, le BCG, peine à conférer une protection suffisante contre la tuberculose pulmonaire, à cause de son immunogénicité peu adaptée. Les auteurs présentent ici une nouvelle souche de BCG recombinante, baptisée BCG::ESX-1Mmar, qui possède une région génomique permettant l’expression et la sécrétion de certains facteurs dont le BCG conventionnel est dépourvu. Ces facteurs accèdent au cytosol de la cellule hôte et constituent des cibles antigéniques privilégiées pour le système immunitaire et par conséquent améliorent l’immunité innée et adaptative contre M. tuberculosis, faisant de BCG::ESX-1Mmar un candidat vaccin prometteur.